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Cat. No.: HY-183551

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Antitubercular agent-59

Antitubercular agent-59 is an orally active antitubercular agent with an IC₅₀ of 51 nM against Mycobacterium tuberculosis H37Rv. Antitubercular agent-59 inhibits growth of Bedaquiline (HY-14881)-resistant Rv0678^G12C mutant strains. Antitubercular agent-59 exerts bactericidal activity in chronic tuberculosis mouse models with 1-Aminobenzotriazole (HY-103389) coadministration.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₂H₂₃N₃O₃
Masse moléculaire:377.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antitubercular agent-59 Chemical Structure

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Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

Antitubercular agent-59 (Compound 6k) potently inhibits the growth of Mycobacterium tuberculosis H37Rv whole cells with an IC₅₀ of 213 nM^[1].
Antitubercular agent-59 shows moderate metabolic clearance in rat hepatocytes and human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitubercular agent-59 (Compound 6k) (100 mg/kg; i.g.; daily 5 days per week; 4 weeks) exhibits bactericidal activity coadministered with 1-Aminobenzotriazole (HY-103389) in chronic mouse infection model of TB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Chronic mouse infection model of TB^[1]
Dosage:

100 mg/kg
Administration:

I.g.; daily 5 days per week; 4 weeks
Result:

Reduced CFU counts to 5.18 log10 CFU/lung when treated with 1-Aminobenzotriazole (100 mg/kg).
Had a mean log10 CFU/lung of 5.97, which was not significantly different from that of untreated control when treated with 6k alone at 100 mg/kg.

Related Protocols :

Bacterial live/dead nucleic-acid viability staining

Chemical Information

Masse moléculaire 377.44
Formule C₂₂H₂₃N₃O₃
SMILES

O=C1C(C(C2=CC=C(N3C[C@@H](C)O[C@@H](C)C3)C=C2)=C1NCC4=NC=CC=C4)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mosallam N, et al. Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of Mycobacterium tuberculosis Displaying Enhanced Metabolic Stability. J Med Chem. 2026 May 14;69(9):10213-10239. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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