ASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. ASK1-IN-12 inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway. ASK1-IN-12 can reduce free fatty acid-induced cholesterol increase, lipid droplet accumulation and improves hepatocellular steatosis. ASK1-IN-12 can be used for the research of non-alcoholic steatohepatitis (NASH).
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- Formule: C24H22F3N9O
- Masse moléculaire:509.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
ASK1-IN-12 (Compound 20) (1-6 μM; 24 h) reduces total cholesterol, triglyceride, low-density lipoprotein cholesterol and lipid droplet accumulation and improves hepatocellular steatosis in free fatty acid-induced LO2 cells[1].
ASK1-IN-12 (1-1000 nM; 24 h) inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway in HepG2 cells[1].
ASK1-IN-12 (0.5-5 μM; 24 h) exhibits no significant cytotoxicity to LO2 hepatocytes, with cell viability maintained above 80%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:1, 10, 100 and 1000 nM
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Incubation Time:24 h
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Result:Reducd the phosphorylation ratios of p-ASK1/ASK1, p-JNK/JNK, and p-p38/p38.
Chemical Information
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Masse moléculaire 509.49
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Formule C24H22F3N9O
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SMILES
O=C(NC1=CC=CC(C2=NN=CN2[C@H](C(F)(F)F)C)=N1)C3=NN4C=CC(C5=CN(C(C)C)N=C5)=CC4=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASK1-IN-12 Related Classifications
HY-179517 Related Classifications
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