COX-2-IN-29
COX-2-IN-29 (Compound 15b) is a selective and orally active COX-2 inhibitor with an IC50 of 0.005 μM.
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- CAS No.: 3033545-21-7
- Formule: C22H23FN2O6S2
- Masse moléculaire:494.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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COX-2 0.005 μM (IC50) |
COX-1 > 10 μM (IC50) |
In Vitro
COX-2-IN-29 (Compound 15b) shows metabolic stability with intrinsic clearance value of 39.9 and 40.3 µL/min/mg protein in mouse and human liver microsomes, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD1 albino mice (23 – 25 g) or male Sprague–Dawley rats weighing approximately 200 – 250 g[1]
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Dosage:10 and 20 mg/kg
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Administration:PO, once
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Result:Induced a reduction of the number of writhes in a statistically significant manner at the minimum dose of 20 mg/kg, while didn’t show any antinociceptive efficacy at 10 mg/kg. Showed a good activity against carrageenan-induced hyperalgesia 30 min after administration, disappearing completely at 1 h after treatment. A very good activity was demonstrated against carrageenan induced edema in the rat paw.
Chemical Information
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CAS No. 3033545-21-7
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Masse moléculaire 494.56
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Formule C22H23FN2O6S2
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SMILES
O=[N+]([O-])OCCS(CCC1=C(C)N(C2=CC=C(F)C=C2)C(C3=CC=C(S(=O)(C)=O)C=C3)=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-29 Related Classifications
HY-150721 Related Classifications
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