CYM 50769
Based on 1 Customer Validation
CYM 50769 is a non-peptidic selective antagonist of neuropeptides B and W receptor 1 (NPBWR1). CYM 50769 can attenuates the NPW-23-induced cell proliferation in ATDC5. CYM 50769 can be used for researching endochondral bone formation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.83%
- CAS No.: 1421365-63-0
- Formule: C24H17ClN2O3
- Masse moléculaire:416.86
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-P1035
Neuropeptide W-23 (human)
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HY-P1248
Neuropeptide FF
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HY-14130
CP 376395
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HY-P1428
RFRP-1(human)
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HY-108625
SHA 68
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HY-108624R
CYM 50769 (Standard)
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HY-108626
ML154
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HY-P1305
CART(55-102)(rat)
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HY-P1304
CART(55-102)(human)
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HY-P1303
CART(62-76)(human,rat)
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HY-108625R
SHA 68 (Standard)
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HY-P1306
Obestatin(rat)
Activité biologique
NPBWR1, GPR7[1]
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
0.12 μM
Compound: 9h, CYM50769
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Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay
Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay
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[PMID: 23287738] |
CYM 50769 (1 and 3 μM; 30 min) attenuates the NPW-23-induced ATDC5 cell proliferation in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ATDC5 (exposed with 200 ng/mL NPW-23 for 24 h)[1]
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Concentration:1 and 3 μM
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Incubation Time:30 min
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Result:Attenuated the NPW-23-induced cell proliferation in a dose-dependent manner.
Chemical Information
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CAS No. 1421365-63-0
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Appearance Solid
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Masse moléculaire 416.86
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Formule C24H17ClN2O3
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Color White to off-white
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SMILES
O=C1C(OC2=CC=C(OC)C=C2)=C(Cl)C=NN1C3C4=C(C5=C3C=CC=C5)C=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (239.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3989 mL | 11.9944 mL | 23.9889 mL | 59.9722 mL |
| 5 mM | 0.4798 mL | 2.3989 mL | 4.7978 mL | 11.9944 mL | |
| 10 mM | 0.2399 mL | 1.1994 mL | 2.3989 mL | 5.9972 mL | |
| 15 mM | 0.1599 mL | 0.7996 mL | 1.5993 mL | 3.9981 mL | |
| 20 mM | 0.1199 mL | 0.5997 mL | 1.1994 mL | 2.9986 mL | |
| 25 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3989 mL | |
| 30 mM | 0.0800 mL | 0.3998 mL | 0.7996 mL | 1.9991 mL | |
| 40 mM | 0.0600 mL | 0.2999 mL | 0.5997 mL | 1.4993 mL | |
| 50 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1994 mL | |
| 60 mM | 0.0400 mL | 0.1999 mL | 0.3998 mL | 0.9995 mL | |
| 80 mM | 0.0300 mL | 0.1499 mL | 0.2999 mL | 0.7497 mL | |
| 100 mM | 0.0240 mL | 0.1199 mL | 0.2399 mL | 0.5997 mL |
CYM 50769 Related Classifications
HY-108624 Related Classifications
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