Diltiazem-d4
Diltiazem-d4 is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation.
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- CAS No.: 112259-41-3
- Formule: C22H22D4N2O4S
- Masse moléculaire:418.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[4]|
L-type calcium channel |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 112259-41-3
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Unlabeled CAS 42399-41-7
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Masse moléculaire 418.54
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Formule C22H22D4N2O4S
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SMILES
CC(O[C@@H]1[C@H](C2=CC=C(C=C2)OC)SC3=CC=CC=C3N(C1=O)C([2H])([2H])C([2H])([2H])N(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[3]. Ito Y, et al. The effects of diltiazem (CRD-401) on the membrane and mechanical properties of vascular smooth muscles of the rabbit. British journal of pharmacology. 1978 Dec;64(4):503-10. [Content Brief]
[4]. Mieth A, et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diltiazem-d4 Related Classifications
HY-B0632S2 Related Classifications
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