DMCM
DMCM is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively.
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- CAS No.: 82499-00-1
- Formule: C17H18N2O4
- Masse moléculaire:314.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Ki: 10 nM (GABAA α1 receptor), 13 nM (GABAA α2 receptor), 7.5 nM (GABAA α3 receptor), 2.2 nM (GABAA α5 receptor)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male γ2I77 mice[2]
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Dosage:20 mg/kg and 60 mg/kg
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Administration:Injected i.p.
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Result:Produced modest anxiolytic-like effects.
Chemical Information
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CAS No. 82499-00-1
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Masse moléculaire 314.34
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Formule C17H18N2O4
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SMILES
O=C(OC)C1=NC=C2NC=3C=C(OC)C(OC)=CC3C2=C1CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32. [Content Brief]
[2]. Leppä E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMCM Related Classifications
HY-100369 Related Classifications
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