DMUP
Based on 1 Customer Validation
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.
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- Pureté: 98.0%
- CAS No.: 2364350-07-0
- Formule: C24H24Cl2N2O10Pt
- Masse moléculaire:766.44
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 μM for A549, A549/DDP, PANC-1, HepG2 cells, respectively[1].
DMUP (5 μM, 24 h) arrests the cell cycle in S phase in A549 cells[1].
DMUP (5 μM, 48 h) induces apoptosis in A549 cells[1].
DMUP (5 μM, 24 h) decreases the expression of CD47 and SIRPα protein[1].
DMUP (5 μM, 4 h) increases the macrophage phagocytosis in A549-GFP cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, A549/DDP, PANC-1, HepG2 cells
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Concentration:0-64 µM
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Incubation Time:72 h
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Result:Showed antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.
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Cell Line:A549 cells
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Concentration:5 µM
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Incubation Time:24 h
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Result:Arrested the cell cycle in the S phase.
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Cell Line:A549 cells
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Concentration:5 µM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
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Cell Line:A549, THP-1 cells
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Concentration:5 µM
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Incubation Time:24 h
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Result:Decreased the expression of CD47 and SIRPα protein.
DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[1]
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Dosage:5, 10, 20, 40 mg/kg
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Administration:i.v., every two days, 18 days
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Result:Showed low toxicity with LD50 of greater than 20 mg/kg.
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Animal Model:A549 xenograft BALB/c nude mice[1]
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Dosage:10 mg/kg
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Administration:i.v., every other day, 17 day
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Result:Showed antitumor activity.
Chemical Information
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CAS No. 2364350-07-0
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Appearance Solid
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Masse moléculaire 766.44
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Formule C24H24Cl2N2O10Pt
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Color White to light yellow
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SMILES
O=C1OC2=C(C(C)=C1)C=CC(OCC([O-][Pt+4]([Cl-])([O-]C(COC3=CC(OC(C=C4C)=O)=C4C=C3)=O)([NH3])([NH3])[Cl-])=O)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMUP Related Classifications
HY-115983 Related Classifications
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