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Cat. No.: HY-187478A

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DOPE-PEG2000-EB1

(Synonyms: DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK)

DOPE-PEG2000-EB1 (DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the EB1 peptide (a penetratin analog). EB1 peptide is an endosomolytic agent that forms an amphipathic alpha helix upon protonation in endosomes, driving endosomal membrane permeabilization. DOPE-PEG2000-EB1 is used for intracellular delivery of nucleic acids (e.g., siRNA) and other macromolecular therapeutics.

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Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-EB1 Chemical Structure

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Description

In Vitro

DOPE-PEG2000-EB1: functionalization of liposomes and nanoparticles for enhanced intracellular delivery of siRNA, nucleic acids, and macromolecular drugs, particularly to overcome the endosomal escape barrier.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes membrane destabilization and fusion under acidic conditions;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization, and extends circulation time;
(3) EB1 peptide; a penetratin analog and endosomolytic agent that forms an amphipathic alpha helix upon protonation in early-to-late endosomes, permeabilizing endosomal membranes and enabling encapsulated cargo (e.g., siRNA) to escape into the cytosol for effective gene silencing.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-EB1]
Synonyms

DOPE-PEG2000-Mal-Cys-LIRLWSHLIHIWFQNRRLKWKKK
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.