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Cat. No.: HY-111999B

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E7766 disodium

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

E7766 disodium is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities.

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CAS No.: 2242636-28-6
Formule: C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂
Masse moléculaire:792.58

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

E7766 disodium Chemical Structure

CAS No.: 2242636-28-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (5)
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Activité biologique

Description

E7766 disodium is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities^[1].

In Vitro

E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC₅₀ values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2242636-28-6
Masse moléculaire 792.58
Formule C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂
SMILES

F[C@@H]1[C@H](O[P@]2(S)=O)[C@@H](CO[P@]3(S)=O)O[C@H]1[N@]4C5=NC=NC(NC/C=C/CNC6=C(N=C[N@]7[C@@H]8O[C@H](CO2)[C@@H](O3)[C@H]8F)C7=NC=N6)=C5N=C4.[Na].[Na]
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Science

Intermetallic nanoassemblies potentiate systemic STING activation. [Abstract]

2026 May 7;392(6798):eadx1893. PMID: 42096576
Science

MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists. [Abstract]

2025 Oct 9;390(6769):eadl4089. PMID: 41066563
J Exp Med

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses. [Abstract]

2026 May 4;223(5):e20251796. PMID: 41874365
Cancer Biol Med

Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression. [Abstract]

2026 Feb 16;23(1):133-153. PMID: 41700809
bioRxiv

2024 September 20.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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E7766 disodium

5 Cited Publications

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Publications (5)
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E7766 disodium

Publications Citing Use of MedChemExpress (MCE) E7766 disodium

Activité biologique

Chemical Information

Publications (5)

Pureté et documentation

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E7766 disodium Related Classifications

HY-111999B Related Classifications