Efzofitimod
Based on 1 Customer Validation
Efzofitimod is a splice variant of the aminoacyl-tRNA synthetase HARS1, which is fused with the Fc segment of a human antibody. Efzofitimod targets the neuronal phospholipid NRP2 (neuropilin-2) and has anti-inflammatory and immunomodulatory activities. Efzofitimod can downregulate the innate and adaptive immune responses in inflammatory disease states, suppressing indirect lung disease (ILD).
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- Pureté: 99.29%
- CAS No.: 2566615-11-8
- Masse moléculaire:64.54 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Human
HARS1
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Homo sapiens HARS1 (histidyl-tRNA synthetase 1)
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Immobilized Efzofitimod can bind Anti-HARS antibody. The EC50 for this effect is 36.03 ng/mL.
Chemical Information
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CAS No. 2566615-11-8
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Appearance Liquid
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Masse moléculaire 64.54 kDa
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Color Colorless to light yellow
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Synonyms
ATYR-1923; KRP-R120
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Efzofitimod
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)