ES-8891
ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis.
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- CAS No.: 129445-88-1
- Formule: C42H60N6O6S
- Masse moléculaire:777.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Chemical Information
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CAS No. 129445-88-1
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Masse moléculaire 777.03
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Formule C42H60N6O6S
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SMILES
O=C(NCCCCCC)C[C@H](O)[C@@H](NC([C@@H](NC([C@@H](NC(CN1CCOCC1)=O)CC2=C3C=CC=CC3=CC=C2)=O)CC4=CSC=N4)=O)CC5CCCCC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ES-8891 Related Classifications
HY-117913 Related Classifications
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