Ethybenztropine
Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent.
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- CAS No.: 524-83-4
- Formule: C22H27NO
- Masse moléculaire:321.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Muscarinic Receptor[1]
In Vitro
Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2].
Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dogs with cardiac arrhythmias[2]
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Dosage:30-60 μg/kg
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Administration:Administered by the fourth ventricle
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Result:Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia.
Converted arrhythmias to sinus rhythms.
Chemical Information
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CAS No. 524-83-4
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Masse moléculaire 321.46
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Formule C22H27NO
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SMILES
CCN([C@@H](CC1)C2)[C@H]1C[C@@H]2OC(C3=CC=CC=C3)C4=CC=CC=C4
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Synonyms
Ponalid; UK 738
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. A K Saxena, et al. Presence of cholinoceptors in mesencephalic raphe nuclei concerned in thermoregulation in rabbits. Clin Exp Pharmacol Physiol. 1984 Mar-Apr;11(2):105-10. [Content Brief]
[2]. M Rozear, et al. Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside. Int J Neuropharmacol. 1968 Jan;7(1):1-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ethybenztropine Related Classifications
HY-118406 Related Classifications
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