Fmoc-Tic-OH
Based on 1 Customer Validation
Fmoc-Tic-OH, an Fmoc-protected derivative of Tic, is a solid-phase peptide synthesis monomer. Fmoc-Tic-OH protects the amino group of Tic via a base-labile Fmoc group, allowing conformationally constrained Tic residues to be stepwise coupled to peptide chains, and the Fmoc protecting group can be removed under piperidine conditions. Fmoc-Tic-OH can be used for peptide synthesis and opioid receptor ligand research.
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- Pureté : 99.38%
- CAS No.: 136030-33-6
- Formule: C25H21NO4
- Masse moléculaire:399.44
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Fmoc-Tic-OH is used in standard Fmoc solid-phase peptide synthesis. In the synthesis of TIPP biotinylated derivatives, Fmoc-Tic-OH is coupled to the growing peptide chain using DIC/HOBt, followed by subsequent coupling of Boc-Tyr (OtBu)-OH, ultimately yielding the biotinylated Tyr-Tic-Phe-Phe-Asp peptide containing a Tic residue[1].
Fmoc-Tic-OH is used in the Fmoc/tBu solid-phase synthesis of H-Dmt-Tic-Xaa series peptides. After the coupling of the C-terminal amino acid, Fmoc-Tic-OH is added and coupled with HATU (4 eq) in DMF for 1 h, followed by subsequent coupling with Boc-Dmt-OH to construct the Dmt-Tic pharmacophore[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 136030-33-6
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Appearance Solid
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Masse moléculaire 399.44
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Formule C25H21NO4
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Color White to off-white
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (250.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (294 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5035 mL | 12.5175 mL | 25.0350 mL | 62.5876 mL |
| 5 mM | 0.5007 mL | 2.5035 mL | 5.0070 mL | 12.5175 mL | |
| 10 mM | 0.2504 mL | 1.2518 mL | 2.5035 mL | 6.2588 mL | |
| 15 mM | 0.1669 mL | 0.8345 mL | 1.6690 mL | 4.1725 mL | |
| 20 mM | 0.1252 mL | 0.6259 mL | 1.2518 mL | 3.1294 mL | |
| 25 mM | 0.1001 mL | 0.5007 mL | 1.0014 mL | 2.5035 mL | |
| 30 mM | 0.0835 mL | 0.4173 mL | 0.8345 mL | 2.0863 mL | |
| 40 mM | 0.0626 mL | 0.3129 mL | 0.6259 mL | 1.5647 mL | |
| 50 mM | 0.0501 mL | 0.2504 mL | 0.5007 mL | 1.2518 mL | |
| 60 mM | 0.0417 mL | 0.2086 mL | 0.4173 mL | 1.0431 mL | |
| 80 mM | 0.0313 mL | 0.1565 mL | 0.3129 mL | 0.7823 mL | |
| 100 mM | 0.0250 mL | 0.1252 mL | 0.2504 mL | 0.6259 mL |
Fmoc-Tic-OH Related Classifications
HY-W013154 Related Classifications
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