Furylfuramide
Furylfuramide is a food preservative that exhibits mutagenic activity. Furylfuramide can be degraded through the aerobic metabolism by liver microsomes.
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- CAS No.: 3688-53-7
- Formule: C11H8N2O5
- Masse moléculaire:248.19
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 3688-53-7
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Appearance Solid
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Masse moléculaire 248.19
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Formule C11H8N2O5
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Color Orange to red
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SMILES
O=C(/C(C1=CC=CO1)=C/C2=CC=C(O2)[N+]([O-])=O)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocole
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tazima Y, et, al. Mutagenicity of nitrofuran derivatives, including furylfuramide, a food preservative. Mutat Res. 1975;32(1):55-80. [Content Brief]
[2]. Shimada T, et, al. Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes. Carcinogenesis. 1990 Jan;11(1):103-10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Furylfuramide Related Classifications
HY-119669 Related Classifications
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