Gardneramine
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines.
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- CAS No.: 34274-91-4
- Formule: C23H28N2O5
- Masse moléculaire:412.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Gardneramine (80 μg/mL; 0-20 min) has inhibitory effect on the atria of guinea pigs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gardneramine (0.2 mg/kg, 0.4 mg/kg; i.a.; single dose) increases blood flow rate and produces vasodilation in the hind limbs of dogs[1].
Gardneramine (20 mg/kg, 40 mg/kg, and 80 mg/kg; i.p.; single dose) inhibits the movement of smooth muscle organs such as the stomach and intestines in mice[1].
Gardneramine (20 mg/kg; p.o.; single dose) mice were treated with small intestine removal, showing relaxation and slight inhibition of stress ion production[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 34274-91-4
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Masse moléculaire 412.48
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Formule C23H28N2O5
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SMILES
COC1=C2C34C5N(C/6)[C@@]([C@](COC4=NC2=C(OC)C=C1OC)([H])[C@@](C6=C\COC)([H])C5)([H])C3
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gardneramine Related Classifications
HY-N3931 Related Classifications
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