FICD - FIC domain protein adenylyltransferase Gene

Also Known as HYPE; HIP13; UNQ3041

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11153

About FICD

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), testis (RPKM 4.5) and 25 other tissues.

Summary

Enables several functions, including ATP binding activity; HSP70 protein binding activity; and chaperone binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

FICD Products (1)

mRNA Protein Name
NM_007076.3 NP_009007.2 protein adenylyltransferase FICD

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables AMPylase activity IDA
IDA: Inferred from direct assay
19362538 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
25435325 GOA
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
25601083 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22266942 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
25435325 GOA
enables protein-folding chaperone binding IDA
IDA: Inferred from direct assay
25601083 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein adenylylation IDA
IDA: Inferred from direct assay
22266942 GOA
involved in regulation of IRE1-mediated unfolded protein response IDA
IDA: Inferred from direct assay
25601083 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
25601083 GOA
Cellular Component GO Annotation Evidence Références Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25601083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FICD Protein Structure

Fic

Fic: Fic/DOC family (285 - 381)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

protein adenylyltransferase FICD

  • AMPylator FICD

FICD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
FICD Q9BVA6 FICD Homo sapiens Q9BVA6
X-Ray Diffraction
25435325
Intra
FICD Q9BVA6 ADK Homo sapiens P55263
Y2H Array
21988832
Intra
FICD Q9BVA6 RAC1 Homo sapiens P63000-1
Ampylation
22266942
Intra
FICD Q9BVA6 FICD Homo sapiens Q9BVA6
GMS
25435325
Intra
FICD Q9BVA6 CDC42 Homo sapiens P60953-2
Ampylation
22266942
Intra
FICD Q9BVA6 FICD Homo sapiens Q9BVA6
SAXS
25435325
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cone-Rod Dystrophy 13

  • CORD13

  • Dystrophy, Cone-Rod, Type 13
Alcoholic Psychosis

  • Psychoses, Alcoholic

  • Alcoholic Psychoses
Progressive Familial Heart Block

  • Hereditary Bundle Branch Defect

  • Hereditary Bundle Branch System Defect

  • Familial Lenegre Disease

  • Familial Lev Disease

  • Familial Lev-Lenegre Disease

  • Familial Pccd

  • Familial Progressive Heart Block

  • Pfhb

  • Bundle Branch Block

  • Hbbd

  • Lenegre Lev Disease

  • Lev Syndrome

  • Lev'S Disease

  • Lev-Lenègre Disease

  • Pccd

  • Progressive Cardiac Conduction Defect

  • Bundle-Branch Block
Schizotypal Personality Disorder

  • Schizotypal Personality
Cholestasis, Progressive Familial Intrahepatic, 1

  • PFIC1

  • Byler Disease

  • Cholestasis, Progressive Familial Intrahepatic 1

  • Progressive Familial Intrahepatic Cholestasis 1

  • Progressive Familial Intrahepatic Cholestasis Type 1

  • Fic1 Deficiency

  • Byler'S Disease

  • Cholestasis, Fatal Intrahepatic

  • Progressive Familial Intrahepatic Cholestasis

  • Severe Atp8b1 Deficiency

  • Fatal Intrahepatic Cholestasis

  • Cholestasis, Intrahepatic, Familial, Progressive, Type 1

  • Progressive Intrahepatic Cholestasis

  • Cholestasis, Progressive Familial Intrahepatic 3
Adult Hepatocellular Carcinoma

  • Adult Primary Hepatocellular Carcinoma

  • Adult Hepatoma

  • Adult Hcc
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04943 FICD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FICD VGNC VGNC:107705
Rattus norvegicus FICD RGD RGD:1359391
Bos taurus FICD VGNC VGNC:29007
Mus musculus FICD MGD MGI:1098550
Macaca mulatta FICD VGNC VGNC:82081
Canis familiaris FICD VGNC VGNC:52933
Others FICD NCBI