Nr0b1 - nuclear receptor subfamily 0, group B, member 1 Gene

Also Known as AHX; Ahc; Ahch; Dax1; DAX-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11614

Summary

This gene encodes an Orphan Nuclear Receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]

Nr0b1 Products (1)

mRNA Protein Name
NM_007430.5 NP_031456.1 nuclear receptor subfamily 0 group B member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA binding IDA
IDA: Inferred from direct assay
10848616 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15155786 MGI
NOT enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27601327 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
15155786 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
23508100 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within Leydig cell differentiation IGI
IGI: Inferred from genetic interaction
15829514 MGI
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
11564714 MGI
acts upstream of or within Sertoli cell differentiation IGI
IGI: Inferred from genetic interaction
15829514 MGI
acts upstream of or within Sertoli cell differentiation IMP
IMP: Inferred from mutant phenotype
11564714 MGI
acts upstream of or within adrenal gland development IGI
IGI: Inferred from genetic interaction
11796523 MGI
acts upstream of or within endodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
16466956 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
12679814 MGI
acts upstream of or within male sex determination IGI
IGI: Inferred from genetic interaction
15944188 MGI
acts upstream of or within male sex determination IMP
IMP: Inferred from mutant phenotype
12679814 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15062575 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23508100 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15155786 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15155786 MGI
acts upstream of or within response to immobilization stress IMP
IMP: Inferred from mutant phenotype
11796523 MGI
acts upstream of or within sex determination IGI
IGI: Inferred from genetic interaction
9486644 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
9843206 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12610109 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10848616 MGI
located in ribosome IDA
IDA: Inferred from direct assay
10848616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 0 group B member 1

  • adrenal hypoplasia congenita-like protein

  • adrenal hypoplasia, congenital homolog

  • nuclear receptor DAX-1

Nr0b1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Nr0b1 Q61066 Pou5f1 Mus musculus P20263
Anti Tag CoIP
20362541
Intra
Nr0b1 Q61066 Pou5f1 Mus musculus P20263
Pull Down
20362541
Intra
Nr0b1 Q61066 Pou5f1 Mus musculus P20263
Anti Tag CoIP
17093407
Intra
Nr0b1 Q61066 Nanog Mus musculus Q80Z64
Anti Tag CoIP
17093407
Intra
Nr0b1 Q61066 Rif1 Mus musculus Q6PR54
Anti Tag CoIP
20362541
Intra
Nr0b1 Q61066 Rif1 Mus musculus Q6PR54
Anti Tag CoIP
17093407
Intra
Nr0b1 Q61066 Esrrb Mus musculus Q61539
Anti Tag CoIP
20362541
Intra
Nr0b1 Q61066 Esrrb Mus musculus Q61539
Pull Down
20362541
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-122054 BPK-29 99.4% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 99.19% Unkown
HY-RS09525 NR0B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21003 Nr0b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27520 Nr0b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr0b1 NCBI NCBI:190