Nanog - Nanog homeobox Gene

Also Known as ENK; Stm1; ecat4; 2410002E02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71950

Summary

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nanog Products (4)

mRNA Protein Name
NM_001289828.1 NP_001276757.1 homeobox protein NANOG isoform 2
NM_001289830.1 NP_001276759.1 homeobox protein NANOG isoform 3
NM_001289831.1 NP_001276760.1 homeobox protein NANOG isoform 3
NM_028016.3 NP_082292.1 homeobox protein NANOG isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12787504 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18957414 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
22988117 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
22988117 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21062744 MGI
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IDA
IDA: Inferred from direct assay
23040477 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
18467660 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
18436640 MGI
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
23798425 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17093407 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18400104 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20123909 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
18957414 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IDA
IDA: Inferred from direct assay
16801560 MGI
involved in cell dedifferentiation IDA
IDA: Inferred from direct assay
23040477 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
12787504 MGI
involved in embryonic pattern specification IEP
IEP: Inferred from expression pattern
15108323 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
17267691 MGI
involved in gonad development IEP
IEP: Inferred from expression pattern
15108323 MGI
acts upstream of mesodermal cell fate commitment IDA
IDA: Inferred from direct assay
16801560 MGI
acts upstream of mesodermal cell fate commitment IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within mesodermal cell fate commitment IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
16801560 MGI
acts upstream of or within negative regulation of cell fate commitment IDA
IDA: Inferred from direct assay
16801560 MGI
acts upstream of or within negative regulation of cell fate commitment IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within negative regulation of stem cell differentiation IDA
IDA: Inferred from direct assay
17940068 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21385842 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18957414 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20937355 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16259959 MGI
acts upstream of or within positive regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
16259959 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20937355 MGI
involved in regulation of stem cell division IDA
IDA: Inferred from direct assay
23040477 MGI
acts upstream of or within response to retinoic acid IDA
IDA: Inferred from direct assay
18400104 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: Inferred from direct assay
16801560 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
12787504 MGI
acts upstream of stem cell differentiation IDA
IDA: Inferred from direct assay
17940068 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
20123909 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
16894029 MGI
acts upstream of or within stem cell division IDA
IDA: Inferred from direct assay
12787505 MGI
involved in stem cell population maintenance IEP
IEP: Inferred from expression pattern
15108323 MGI
acts upstream of or within stem cell population maintenance IGI
IGI: Inferred from genetic interaction
17938240 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
25825768 MGI
Cellular Component GO Annotation Evidence References Source
is active in chromatin IDA
IDA: Inferred from direct assay
23798425 MGI
NOT located in condensed chromosome IMP
IMP: Inferred from mutant phenotype
27723719 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
21076177 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
23798425 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15582778 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein NANOG

  • ES cell-associated protein 4

  • early embryo specific expression NK family

  • early embryo specific expression NK-type homeobox protein

  • homeobox transcription factor Nanog

Nanog Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nanog Q80Z64 Pou5f1 Mus musculus P20263
Anti Tag CoIP
17093407
Intra
Nanog Q80Z64 Pou5f1 Mus musculus P20263
Pull Down
17093407
Intra
Nanog Q80Z64 Rif1 Mus musculus Q6PR54
TAP
17093407
Intra
Nanog Q80Z64 Rif1 Mus musculus Q6PR54
Anti Bait CoIP
17093407
Intra
Nanog Q80Z64 Rif1 Mus musculus Q6PR54
Pull Down
17093407
Intra
Nanog Q80Z64 Nr0b1 Mus musculus Q61066
Pull Down
17093407
Intra
Nanog Q80Z64 Nr0b1 Mus musculus Q61066
Anti Tag CoIP
23892456
Intra
Nanog Q80Z64 Nr0b1 Mus musculus Q61066
TAP
17093407
Intra
Nanog Q80Z64 Nr0b1 Mus musculus Q61066
Anti Tag CoIP
17093407
Intra
Nanog Q80Z64 Slc8a1 Mus musculus P70414
Pull Down
17093407
Intra
Nanog Q80Z64 Slc8a1 Mus musculus P70414
Anti Tag CoIP
17093407
Intra
Nanog Q80Z64 Slc8a1 Mus musculus P70414
TAP
17093407
Intra
Nanog Q80Z64 Znf281 Mus musculus Q99LI5
Pull Down
17093407
Intra
Nanog Q80Z64 Znf281 Mus musculus Q99LI5
Anti Tag CoIP
17093407
Intra
Nanog Q80Z64 Znf281 Mus musculus Q99LI5
Anti Tag CoIP
23892456
Intra
Nanog Q80Z64 Sox2 Mus musculus P48432
Pull Down
23892456
Intra
Nanog Q80Z64 Sox2 Mus musculus P48432
Anti Tag CoIP
23892456
Intra
Nanog Q80Z64 Pin1 Mus musculus Q9QUR7
Anti Bait CoIP
20622153
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0356A Ciprofloxacin monohydrochloride 99.86% Unkown
HY-B0356B Ciprofloxacin hydrochloride monohydrate 99.88% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17602 Amcasertib Inducer 98.03% Phase 2

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12303 OAC1 Activator 99.85% Unkown
HY-18772 O4I2 99.18% Unkown
HY-18771 O4I1 Activator 98.05% Unkown
HY-119672 Oct4 inducer-1 Activator 99.92% Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-129108 9-cis-UAB30 / Unkown
HY-168566 EV206 Inhibitor 99.62% Unkown
HY-168885 ZSH-512 / Unkown
HY-179339 LSD1-IN-46 Inhibitor / Unkown
HY-B0356G Ciprofloxacin (GMP) / Unkown
HY-RS09019 NANOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119666 Rooperol Activator / Unkown
HY-174574 Human NANOG mRNA / Unkown
HY-N15201 Betavulgarin Inhibitor / Unkown
HY-RS19720 Nanog Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26216 Nanog Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nanog NCBI NCBI:79923