Cap1 - CAP, adenylate cyclase-associated protein 1 (yeast) Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12331

Summary

The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]

Cap1 Products (4)

mRNA Protein Name
NM_001301067.2 NP_001287996.1 adenylyl cyclase-associated protein 1
NM_001358035.1 NP_001344964.1 adenylyl cyclase-associated protein 1
NM_001358036.1 NP_001344965.1 adenylyl cyclase-associated protein 1
NM_007598.5 NP_031624.2 adenylyl cyclase-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15004221 MGI
acts upstream of or within ameboidal-type cell migration IMP
IMP: Inferred from mutant phenotype
15004221 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
7691848 MGI
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
36264429 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
36264429 MGI
acts upstream of or within receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15004221 MGI
Cellular Component GO Annotation Evidence Références Source
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
15004221 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
7691848 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
36264429 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
36264429 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
36264429 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
36264429 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
36264429 MGI
is active in presynapse IMP
IMP: Inferred from mutant phenotype
36264429 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylyl cyclase-associated protein 1

  • adenylyl cyclase-associated CAP protein, yeast homolog 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-A0148A Halofantrine hydrochloride Inhibitor 99.90% Yes
HY-A0148 Halofantrine Inhibitor / Unkown
HY-A0148AR Halofantrine hydrochloride (Standard) Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-174497 eGFP mRNA 90% Unkown
HY-145973A 3'OMe-m7GpppAmpG ammonium solution (100 mM) Inhibitor 98.24% Unkown
HY-E70081 mRNA Cap 2'-O-methyltransferase / Unkown
HY-145973 3'OMe-m7GpppAmpG Inhibitor / Unkown
HY-145973AGL 3'OMe-m7GpppAmpG ammonium solution (100 mM) (GMP Like) Inhibitor / Unkown
HY-145973B 3'OMe-m7GpppAmpG Tris Inhibitor / Unkown
HY-145979 m7GpppUmpG / Unkown
HY-145980 m7GpppUpG / Unkown
HY-145981 m7GpppCpG / Unkown
HY-145982 m7GpppCmpG / Unkown
HY-185611 A(5')ppp(5')(2'-OMeA)pG tetraammonium / Unkown
HY-D0869S 3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 / Unkown
HY-RS01880 CAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11259 PRSS8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14969 TRAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145976 m7GpppGpG / Unkown
HY-RS17877 Cap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17996 Traf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18185 Prss8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24071 Park7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24346 Cap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24659 Prss8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cap1 NCBI NCBI:10487