Ppp2ca - protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Gene

Also Known as PP2A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19052

Summary

Enables GABA Receptor binding activity and protein C-terminus binding activity. Acts upstream of or within mesoderm development. Located in chromosome, centromeric region; cytosol; and plasma membrane. Part of protein Phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PPP2CA (protein Phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2ca Products (1)

mRNA Protein Name
NM_019411.4 NP_062284.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GABA receptor binding IDA
IDA: Inferred from direct assay
16754670 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9920888 MGI
enables protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
26974206 MGI
Biological Process GO Annotation Evidence Références Source
involved in T cell homeostasis IMP
IMP: Inferred from mutant phenotype
26974206 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
9770493 MGI
involved in negative regulation of glycolytic process through fructose-6-phosphate IMP
IMP: Inferred from mutant phenotype
32192773 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
26974206 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
28465465 MGI
Cellular Component GO Annotation Evidence Références Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
18084284 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9882488 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12885400 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10781942 MGI
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
16717086 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16420440 MGI
is active in synapse IEP
IEP: Inferred from expression pattern
16420440 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

  • PP2A-alpha

Ppp2ca Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Ppp2ca P63330 Ppp2r1a Mus musculus Q76MZ3
Anti Bait CoIP
19818709
Intra
Ppp2ca P63330 Igbp1 Mus musculus Q61249
Anti Bait CoIP
19818709
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11007 PPP2CA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21174 Ppp2ca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27691 Ppp2ca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp2ca NCBI NCBI:5515