USP22 - ubiquitin specific peptidase 22 Gene

Also Known as USP3L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23326

About USP22

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:20,999,596-21,043,419 (from NCBI)

This gene has 11 transcripts (splice variants), 221 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues.

Summary

Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent Deubiquitinase. Contributes to H4 Histone Acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]

USP22 Products (1)

mRNA Protein Name
NM_015276.2 NP_056091.1 ubiquitin carboxyl-terminal hydrolase 22

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
16378762 GOA
contributes to cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
18206973 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables histone H2A deubiquitinase activity IDA
IDA: Inferred from direct assay
18469533 GOA
enables histone H2B deubiquitinase activity IDA
IDA: Inferred from direct assay
18469533 GOA
contributes to histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
18206973 GOA
enables nuclear receptor coactivator activity IMP
IMP: Inferred from mutant phenotype
18206972 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18206972 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
18206972 GOA
Biological Process GO Annotation Evidence Références Source
involved in G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
27030811 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18206973 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
18206973 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
32130408 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
16378762 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9603525 GOA
Cellular Component GO Annotation Evidence Références Source
part of SAGA complex IDA
IDA: Inferred from direct assay
18206972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP22 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (63 - 123)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (176 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 22

  • deubiquitinating enzyme 22

USP22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
USP22 Q9UPT9 FUBP1 Homo sapiens Q96AE4
Anti Tag CoIP
21779003
Intra
USP22 Q9UPT9 AASDHPPT Homo sapiens Q9NRN7
Validated Y2H
25416956
Intra
USP22 Q9UPT9 AASDHPPT Homo sapiens Q9NRN7
Y2H Array
25416956
Intra
USP22 Q9UPT9 AASDHPPT Homo sapiens Q9NRN7
Anti Tag CoIP
19615732
Cross: Cross-species interaction Intra: Intraspecies interaction

USP22 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81589 USP22 Antibody (YA1334) WB, ICC/IF, IP, FC Human

Related Diseases

Diseases Alias
Glandular Tularemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15533 USP22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16944 Usp22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23387 Usp22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP22 RGD RGD:1310354
Bos taurus USP22 VGNC VGNC:36716
Canis familiaris USP22 VGNC VGNC:55013
Macaca mulatta USP22 VGNC VGNC:78742
Felis catus USP22 VGNC VGNC:66873
Mus musculus USP22 MGD MGI:2144157
Others USP22 NCBI