ISG20 - interferon stimulated exonuclease gene 20 Gene

Also Known as CD25; HEM45

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3669

About ISG20

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,635,632-88,656,483 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 5 paralogues. Biased expression in lymph node (RPKM 12.2), spleen (RPKM 8.7) and 13 other tissues.

Summary

Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ISG20 Products (6)

mRNA Protein Name
NM_001303233.2 NP_001290162.1 interferon-stimulated gene 20 kDa protein isoform a
NM_001303234.2 NP_001290163.1 interferon-stimulated gene 20 kDa protein isoform a
NM_001303235.2 NP_001290164.1 interferon-stimulated gene 20 kDa protein isoform b
NM_001303236.2 NP_001290165.1 interferon-stimulated gene 20 kDa protein isoform b
NM_001303237.2 NP_001290166.1 interferon-stimulated gene 20 kDa protein isoform c
NM_002201.6 NP_002192.2 interferon-stimulated gene 20 kDa protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
11401564 GOA
enables U1 snRNA binding IDA
IDA: Inferred from direct assay
16514659 GOA
enables U2 snRNA binding IDA
IDA: Inferred from direct assay
16514659 GOA
enables U3 snoRNA binding IDA
IDA: Inferred from direct assay
16514659 GOA
enables exonuclease activity IMP
IMP: Inferred from mutant phenotype
21036379 GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
IDA: Inferred from direct assay
11401564 GOA
Biological Process GO Annotation Evidence Références Source
involved in DNA catabolic process IDA
IDA: Inferred from direct assay
11401564 GOA
involved in RNA catabolic process IDA
IDA: Inferred from direct assay
11401564 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
21036379 GOA
involved in negative regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
21036379 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
12594219 GOA
Cellular Component GO Annotation Evidence Références Source
located in Cajal body IDA
IDA: Inferred from direct assay
16514659 GOA
located in PML body IDA
IDA: Inferred from direct assay
9235947 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16514659 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16514659 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21036379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISG20 Protein Structure

RNase_T

RNase_T: Exonuclease (8 - 162)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

interferon-stimulated gene 20 kDa protein

  • estrogen-regulated transcript 45 protein

Related Diseases

Diseases Alias
Hepatitis C

  • Chronic Hepatitis C

  • Hepatitis C Infection

  • Hepatitis Nona Nonb

  • Nanbh

  • Viral Hepatitis C

  • Hepatitis C Chronic

  • Hepatitis C, Chronic

  • Chronic Type C Viral Hepatitis

  • Chronic Hcv - [Hepatitis C Virus] Infection

  • Hepatitis C Nos

  • Hepatitis C Infection Nos

  • Hepatitis C-Related Cirrhosis

  • Type C Viral Hepatitis

  • Hep C Nos
Estrogen-Receptor Positive Breast Cancer
Subacute Delirium

  • Delirium

  • Acute Confusional State Nos
Yellow Fever

  • Urban Yellow Fever

  • Jungle Yellow Fever

  • Sylvatic Yellow Fever

  • Yf

  • Yellow Fever, Sylvan

  • Bronze John

  • Yellow Jack

  • Yf- [Yellow Fever]

  • Febris Flava
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Microphthalmia With Limb Anomalies

  • Waardenburg Anophthalmia Syndrome

  • Ophthalmoacromelic Syndrome

  • OAS

  • MLA

  • Anophthalmia-Syndactyly

  • Anophthalmia-Syndactyly Syndrome

  • Anophthalmos With Limb Anomalies

  • Anophthalmia Waardenburg Syndrome

  • Anophthalmos-Syndactyly

  • Ophthalmo-Acromelic Syndrome

  • Anophthalmia-Waardenburg Syndrome

  • Anophthalmos-Limb Anomalies Syndrome

  • Syndactyly-Anophthalmos Syndrome

  • Microphthalmia, With Limb Anomalies
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-125980 LX-3 Inhibitor 98.08% Unkown
HY-RS06930 ISG20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20043 Isg20 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26546 Isg20 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ISG20 VGNC VGNC:67833
Bos taurus ISG20 VGNC VGNC:30294
Macaca mulatta ISG20 VGNC VGNC:73769
Canis familiaris ISG20 VGNC VGNC:42107
Mus musculus ISG20 MGD MGI:1928895
Rattus norvegicus ISG20 RGD RGD:1306407
Others ISG20 NCBI