NFRKB - nuclear factor related to kappaB binding protein Gene

Also Known as INO80G

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4798

About NFRKB

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,863,636-129,895,578 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 11.1), ovary (RPKM 7.8) and 25 other tissues.

Summary

Enables protease binding activity. Predicted to be involved in DNA recombination and DNA repair. Located in nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

NFRKB Products (2)

mRNA Protein Name
NM_001143835.2 NP_001137307.1 nuclear factor related to kappa-B-binding protein isoform 1
NM_006165.4 NP_006156.2 nuclear factor related to kappa-B-binding protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protease binding IPI
IPI: Inferred from physical interaction
18922472 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18922472 GOA
Biological Process GO Annotation Evidence Références Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
21303910 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27641337 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of DNA strand elongation IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
26340092 GOA
involved in regulation of chromosome organization IMP
IMP: Inferred from mutant phenotype
26340092 GOA
Cellular Component GO Annotation Evidence Références Source
part of Ino80 complex IDA
IDA: Inferred from direct assay
18922472 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18922472 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFRKB Protein Structure

NFRKB_winged

NFRKB_winged: NFRKB Winged Helix-like (379 - 478)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1299 a.a.
Protein Preferred Names Protein Names

nuclear factor related to kappa-B-binding protein

  • DNA-binding protein R kappa B

NFRKB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NFRKB Q6P4R8 UCHL5 Homo sapiens Q9Y5K5
Y2H Array
25416956
Intra
NFRKB Q6P4R8 UCHL5 Homo sapiens Q9Y5K5
Pull Down
18922472
Intra
NFRKB Q6P4R8 UCHL5 Homo sapiens Q9Y5K5
Y2H
18922472
Intra
NFRKB Q6P4R8 UCHL5 Homo sapiens Q9Y5K5-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Jacobsen Syndrome

  • Chromosome 11q Deletion Syndrome

  • Partial 11q Monosomy Syndrome

  • Jacobsen Distal 11q Deletion Syndrome

  • JBS

  • 11q Partial Monosomy Syndrome

  • Chromosome 11q Deletion

  • 11q Deletion

  • 11q Monosomy

  • Deletion 11q

  • Monosomy 11q

  • Partial Monosomy 11q

  • 11q Deletion Disorder

  • 11q Deletion Syndrome

  • 11q Terminal Deletion Disorder

  • 11q- Deletion Syndrome

  • 11q23 Deletion Disorder

  • Jacobsen Thrombocytopenia

  • 11q Terminal Deletion Syndrome

  • Del(11)(Q23.3)

  • Del(11)(Qter)

  • Distal Deletion 11q

  • Distal Monosomy 11q

  • Monosomy 11qter

  • Telomeric Deletion 11q

  • Paris-Trousseau Thrombocytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09266 NFRKB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22677 Nfrkb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29191 Nfrkb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NFRKB RGD RGD:1310558
Bos taurus NFRKB VGNC VGNC:32051
Felis catus NFRKB VGNC VGNC:68489
Mus musculus NFRKB MGD MGI:2442410
Macaca mulatta NFRKB VGNC VGNC:75343
Canis familiaris NFRKB VGNC VGNC:43786
Others NFRKB NCBI