OPRL1 - opioid related nociceptin receptor 1 Gene

Also Known as NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; PNOCR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4987

About OPRL1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:64,080,082-64,100,643 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 202 orthologues and 17 paralogues. Broad expression in brain (RPKM 1.7), testis (RPKM 0.9) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

OPRL1 Products (13)

mRNA Protein Name
XM_047440154.1 XP_047296110.1 nociceptin receptor isoform X2
NM_182647.4 NP_872588.1 nociceptin receptor isoform 1
NM_001318853.2 NP_001305782.1 nociceptin receptor isoform 1x
XM_047440153.1 XP_047296109.1 nociceptin receptor isoform X1
NM_001318855.1 NP_001305784.1 nociceptin receptor isoform 3
NM_001200019.2 NP_001186948.1 nociceptin receptor isoform 1
XM_047440156.1 XP_047296112.1 nociceptin receptor isoform X3
XM_011528828.4 XP_011527130.1 nociceptin receptor isoform X1
XM_011528830.4 XP_011527132.1 nociceptin receptor isoform X4
NM_001318854.1 NP_001305783.1 nociceptin receptor isoform 2
NM_000913.6 NP_000904.1 nociceptin receptor isoform 1
XM_047440157.1 XP_047296113.1 nociceptin receptor isoform X4
XM_047440155.1 XP_047296111.1 nociceptin receptor isoform X3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
8137918 GOA
enables G protein-coupled receptor activity IPI
IPI: Inferred from physical interaction
10571060 GOA
enables nociceptin receptor activity IDA
IDA: Inferred from direct assay
10571060 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
Biological Process GO Annotation Evidence Références Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8137918 GOA
acts upstream of or within positive effect calcium-mediated signaling IDA
IDA: Inferred from direct assay
10571060 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IPI
IPI: Inferred from physical interaction
10571060 GOA
Cellular Component GO Annotation Evidence Références Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8137918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPRL1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (68 - 319)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

nociceptin receptor

  • kappa-type 3 opioid receptor

  • kappa3-related opioid receptor

  • nociceptin/orphanin FQ receptor

  • opiate receptor-like 1

  • orphanin FQ receptor

OPRL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
OPRL1 P41146 CERS6 Homo sapiens Q6ZMG9
Anti Tag CoIP
28298427
Intra
OPRL1 P41146 CERS6 Homo sapiens Q6ZMG9
Anti Tag CoIP
33961781
Intra
OPRL1 P41146 Q13519-PRO_0000008327 Homo sapiens Q13519-PRO_0000008327
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pain Agnosia

  • Analgesia
Drug Dependence
Withdrawal Disorder

  • Withdrawal Syndrome

  • Substance Withdrawal Syndrome
Opioid Abuse

  • Opioid-Related Disorders
Slate Pneumoconiosis

  • Schistosis
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcohol Dependence, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Ivic Syndrome

  • Oculootoradial Syndrome

  • Radial Ray Defects, Hearing Impairment, External Ophthalmoplegia, And Thrombocytopenia

  • IVIC

  • Instituto Venezolano De Investigaciones Cientificas Syndrome

  • Oculo-Oto-Radial Syndrome

  • Oors
Opiate Dependence

  • Opioid Dependence

  • Opioid Addiction

  • Opiate Addiction

  • Opioid Type Dependence

  • Opioid-Related Disorders

  • Opium Dependence

  • Narcotic Dependence

  • Intravenous Narcotism

  • Narcotism Nos

  • Oral Narcotism Nos
Psoriasis 7

  • PSORS7

  • Psoriasis 7, Susceptibility To

  • Psoriasis Susceptibility 7

  • Psoriasis

  • Psoriasis Vulgaris

  • Pv
Neonatal Abstinence Syndrome

  • Drug Withdrawal Syndrome In Newborn
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09803 OPRL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09804 Oprl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09805 Oprl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris OPRL1 VGNC VGNC:44134
Rattus norvegicus OPRL1 RGD RGD:68438
Bos taurus OPRL1 VGNC VGNC:32440
Mus musculus OPRL1 MGD MGI:97440
Macaca mulatta OPRL1 VGNC VGNC:97110
Felis catus OPRL1 VGNC VGNC:68634
Others OPRL1 NCBI