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SDF4 - stromal cell derived factor 4 Gene

Also Known as Cab45; SDF-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51150

About SDF4

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,216,931-1,232,001 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 31.3), kidney (RPKM 26.5) and 25 other tissues.

Summary

This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011]

SDF4 Products (2)

mRNA	Protein	Name
NM_016176.6	NP_057260.3	45 kDa calcium-binding protein isoform 2 precursor
NM_016547.3	NP_057631.2	45 kDa calcium-binding protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	17442889	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17442889	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in maintenance of synapse structure	IGI IGI: Inferred from genetic interaction	33667157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDF4 Protein Structure

EF-hand_7

EF-hand_5

0
100
200
300
362 a.a.

Protein Preferred Names	Protein Names
45 kDa calcium-binding protein

SDF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SDF4	Q9BRK5	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	SDF4	Q9BRK5	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	SDF4	Q9BRK5	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	SDF4	Q9BRK5	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	SDF4	Q9BRK5	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	SDF4	Q9BRK5	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Crustacean Allergy
Shrimp Allergy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12589	SDF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SDF4	RGD	RGD:621521
Bos taurus	SDF4	VGNC	VGNC:34387
Macaca mulatta	SDF4	VGNC	VGNC:77092
Felis catus	SDF4	VGNC	VGNC:64949
Mus musculus	SDF4	MGD	MGI:108079
Canis familiaris	SDF4	VGNC	VGNC:45948
Others	SDF4	NCBI