POLR2C - RNA polymerase II subunit C Gene

Also Known as RPB3; RPB31; hRPB33; hsRPB3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5432

About POLR2C

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,462,679-57,472,009 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 43.5), adrenal (RPKM 39.1) and 25 other tissues.

Summary

This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

POLR2C Products (1)

mRNA	Protein	Name
NM_032940.3	NP_116558.1	DNA-directed RNA polymerase II subunit RPB3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12860379	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9852112	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of RNA polymerase II, core complex	IDA IDA: Inferred from direct assay	9852112	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9852112	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2C Protein Structure

RNA_pol_L

RNA_pol_A_bac

0
100
200
275 a.a.

Protein Preferred Names	Protein Names
DNA-directed RNA polymerase II subunit RPB3	DNA-directed RNA polymerase II 33 kDa polypeptide

POLR2C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	POLR2C	P19387	ATF4	Homo sapiens	P18848	Y2H	12860379
Intra	POLR2C	P19387	ATF4	Homo sapiens	P18848	Pull Down	12860379

Cross: Cross-species interaction Intra: Intraspecies interaction

POLR2C Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82702	RNA Polymerase II Subunit B3 Antibody (YA2447)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
Nemaline Myopathy 7	NEM7 Nemaline Myopathy 7, Autosomal Recessive Cfl2-Related Nemaline Myopathy Myopathy, Nemaline, Type 7
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS10844	POLR2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POLR2C	RGD	RGD:1306935
Macaca mulatta	POLR2C	VGNC	VGNC:76212
Bos taurus	POLR2C	VGNC	VGNC:33137
Canis familiaris	POLR2C	VGNC	VGNC:44794
Mus musculus	POLR2C	MGD	MGI:109299
Others	POLR2C	NCBI