HAUS4 - HAUS augmin like complex subunit 4 Gene

Also Known as C14orf94

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54930

About HAUS4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,946,228-22,957,090 (from NCBI)

This gene has 21 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in ovary (RPKM 23.6), bone marrow (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

HAUS4 Products (3)

mRNA Protein Name
NM_001166269.2 NP_001159741.1 HAUS augmin-like complex subunit 4 isoform 1
NM_001166270.2 NP_001159742.1 HAUS augmin-like complex subunit 4 isoform 2
NM_017815.3 NP_060285.2 HAUS augmin-like complex subunit 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
19369198 GOA
Biological Process GO Annotation Evidence Références Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
19427217 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
19369198 GOA
Cellular Component GO Annotation Evidence Références Source
part of HAUS complex IDA
IDA: Inferred from direct assay
19369198 GOA
part of HAUS complex IPI
IPI: Inferred from physical interaction
20360068 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS4 Protein Structure

HAUS4

HAUS4: HAUS augmin-like complex subunit 4 (127 - 360)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
Protein Preferred Names Protein Names

HAUS augmin-like complex subunit 4

  • homologous to Augmin subunits

HAUS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
HAUS4 Q9H6D7 HAUS1 Homo sapiens Q96CS2
GMS
25173975
Intra
HAUS4 Q9H6D7 HAUS1 Homo sapiens Q96CS2
TAP
20360068
Intra
HAUS4 Q9H6D7 HAUS6 Homo sapiens Q7Z4H7
TAP
20360068
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Enamel Caries

  • Primary Dental Caries

  • Dental Caries Limited To Enamel

  • Simple Dental Cavity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06016 HAUS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HAUS4 MGD MGI:1261794
Felis catus HAUS4 VGNC VGNC:104399
Rattus norvegicus HAUS4 RGD RGD:1305288
Others HAUS4 NCBI