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IPO4 - importin 4 Gene

Also Known as Imp4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79711

About IPO4

This gene has 21 transcripts (splice variants), 1 gene allele, 195 orthologues and 5 paralogues. Broad expression in testis (RPKM 33.8), thyroid (RPKM 8.4) and 25 other tissues.

Summary

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and protein import into nucleus. Located in chromatin. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

IPO4 Products (1)

mRNA	Protein	Name
NM_024658.4	NP_078934.3	importin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	16207705	GOA
enables nuclear localization sequence binding	IDA IDA: Inferred from direct assay	17682055	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17616579	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	11823430	GOA
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	14718166	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in chromatin	IDA IDA: Inferred from direct assay	14718166	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPO4 Protein Structure

IBN_N

HEAT_2

HEAT_EZ

0
200
400
600
800
1000
1081 a.a.

Protein Preferred Names	Protein Names
importin-4	imp4b

IPO4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	IPO4	Q8TEX9	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	IPO4	Q8TEX9	CEBPD	Homo sapiens	P49716	Anti Bait CoIP	20805509

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N6896	Isoviolanthin	Inhibitor	99.87%	Unkown
HY-RS06868	IPO4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IPO4	VGNC	VGNC:73630
Mus musculus	IPO4	MGD	MGI:1923001
Felis catus	IPO4	VGNC	VGNC:62955
Canis familiaris	IPO4	VGNC	VGNC:42065
Rattus norvegicus	IPO4	RGD	RGD:1305206
Bos taurus	IPO4	VGNC	VGNC:30242
Others	IPO4	NCBI