TASL - TLR adaptor interacting with endolysosomal SLC15A4 Gene

Also Known as CXorf21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80231

About TASL

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,558,809-30,577,766 (from NCBI)

This gene has 1 transcript (splice variant) and 185 orthologues. Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 6.2) and 17 other tissues.

Summary

Involved in positive regulation of innate immune response; positive regulation of Toll-like Receptor signaling pathway; and regulation of lysosomal lumen pH. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

TASL Products (1)

mRNA Protein Name
NM_025159.3 NP_079435.1 TLR adapter interacting with SLC15A4 on the lysosome

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
32433612 GOA
involved in positive regulation of toll-like receptor 7 signaling pathway IMP
IMP: Inferred from mutant phenotype
32433612 GOA
involved in positive regulation of toll-like receptor 8 signaling pathway IMP
IMP: Inferred from mutant phenotype
32433612 GOA
involved in regulation of lysosomal lumen pH IDA
IDA: Inferred from direct assay
31001245 GOA
Cellular Component GO Annotation Evidence Références Source
located in endolysosome membrane IDA
IDA: Inferred from direct assay
32433612 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TASL Protein Structure

DUF4569

DUF4569: Domain of unknown function (DUF4569) (1 - 298)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

TLR adapter interacting with SLC15A4 on the lysosome

  • 5430427O19Rik

TASL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TASL Q9HAI6 SLC15A4 Homo sapiens Q8N697
TAP
32433612
Intra
TASL Q9HAI6 SLC15A4 Homo sapiens Q8N697
Anti Tag CoIP
33961781
Intra
TASL Q9HAI6 SLC15A4 Homo sapiens Q8N697
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lupus Erythematosus

  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]
Immunodeficiency 33

  • IMD33

  • X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

  • X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

  • X-Linked Msmd Due To Ikbkg Deficiency

  • X-Linked Msmd Due To Nemo Deficiency

  • Invasive Pneumococcal Disease, Recurrent Isolated, 2

  • Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

  • Ipd2, Formerly

  • Nf-Kappa B Essential Modulator Deficiency

  • Familial X-Linked 1 Atypical Mycobacteriosis

  • Nemo Deficiency Syndrome

  • Amcbx1

  • Familial, X-Linked, Atypical Mycobacteriosis 1

  • Ipd2

  • Recurrent Isolated Invasive Pneumococcal Disease 2

  • X-Linked Disseminated Atypical Mycobacterial Infection Type 1

  • X-Linked Immunodeficiency 33, Mycobacteriosis

  • X-Linked Susceptibility To Mycobacterial Disease Type 1

  • Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

  • Atypical Mycobacteriosis, Familial, X-Linked 1
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14221 TASL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TASL VGNC VGNC:52591
Macaca mulatta TASL VGNC VGNC:71573
Rattus norvegicus TASL RGD RGD:1565785
Mus musculus TASL MGD MGI:1918648
Bos taurus TASL VGNC VGNC:56524
Felis catus TASL VGNC VGNC:61301
Others TASL NCBI