TCL1A - TCL1 family AKT coactivator A Gene
Also Known as TCL1
Species: Homo sapiens
About TCL1A
This gene has 9 transcripts (splice variants), 106 orthologues, 2 paralogues and is associated with 45 phenotypes. Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues.
Summary
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase Akt (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
TCL1A Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001098725.2 | NP_001092195.1 | T-cell leukemia/lymphoma protein 1A |
| NM_021966.3 | NP_068801.1 | T-cell leukemia/lymphoma protein 1A |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables identical protein binding |
IDA
IDA: Inferred from direct assay
|
10983986 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
10983986 | GOA |
| enables protein serine/threonine kinase activator activity |
IDA
IDA: Inferred from direct assay
|
10983986 | GOA |
| enables protein serine/threonine kinase activator activity |
IMP
IMP: Inferred from mutant phenotype
|
10983986 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in intracellular signal transduction |
IDA
IDA: Inferred from direct assay
|
10983986 | GOA |
TCL1A Protein Structure
TCL1_MTCP1: TCL1/MTCP1 family (1 - 112)
- 0
- 100
- 114 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
T-cell leukemia/lymphoma protein 1A |
|
TCL1A Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
TCL1A | P56279 | TP53BP2 | Homo sapiens | Q13625-3 | 25416956 | |
|
Intra
|
TCL1A | P56279 | TP53BP2 | Homo sapiens | Q13625-3 | 25416956 | |
|
Intra
|
TCL1A | P56279 | AKT1 | Homo sapiens | B0LPE5 | 25416956 | |
|
Intra
|
TCL1A | P56279 | AKT1 | Homo sapiens | B0LPE5 | 25416956 | |
|
Intra
|
TCL1A | P56279 | AKT1 | Homo sapiens | B0LPE5 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CADPS | Homo sapiens | A2RRN7 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CADPS | Homo sapiens | A2RRN7 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CADPS | Homo sapiens | A2RRN7 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CADPS | Homo sapiens | A2RRN7 | 25416956 | |
|
Intra
|
TCL1A | P56279 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
TCL1A | P56279 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
TCL1A | P56279 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
TCL1A | P56279 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CCDC13 | Homo sapiens | Q8IYE1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CCDC13 | Homo sapiens | Q8IYE1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CCDC13 | Homo sapiens | Q8IYE1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
TCL1A | P56279 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
TCL1A | P56279 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TNKS | Homo sapiens | O95271 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TNKS | Homo sapiens | O95271 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TEPSIN | Homo sapiens | Q96N21 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TEPSIN | Homo sapiens | Q96N21 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TEPSIN | Homo sapiens | Q96N21 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CARD9 | Homo sapiens | Q9H257-2 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TTC33 | Homo sapiens | Q6PID6 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TTC33 | Homo sapiens | Q6PID6 | 25416956 | |
|
Intra
|
TCL1A | P56279 | NFKBIA | Homo sapiens | P25963 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NFKBIA | Homo sapiens | P25963 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LSM3 | Homo sapiens | P62310 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LSM3 | Homo sapiens | P62310 | 25416956 | |
|
Intra
|
TCL1A | P56279 | LSM3 | Homo sapiens | P62310 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LSM3 | Homo sapiens | P62310 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LSM3 | Homo sapiens | P62310 | 25416956 | |
|
Intra
|
TCL1A | P56279 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRAF1 | Homo sapiens | Q13077 | 25416956 | |
|
Intra
|
TCL1A | P56279 | TRAF1 | Homo sapiens | Q13077 | 27107012 | |
|
Intra
|
TCL1A | P56279 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRAF1 | Homo sapiens | Q13077 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TXLNA | Homo sapiens | P40222 | 25416956 | |
|
Intra
|
TCL1A | P56279 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TXLNA | Homo sapiens | P40222 | 33961781 | |
|
Intra
|
TCL1A | P56279 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
TCL1A | P56279 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
TCL1A | P56279 | TXLNB | Homo sapiens | Q8N3L3 | 25416956 | |
|
Intra
|
TCL1A | P56279 | GOLGA2 | Homo sapiens | Q08379 | 27107012 | |
|
Intra
|
TCL1A | P56279 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
TCL1A | P56279 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
TCL1A | P56279 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
TCL1A | P56279 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
TCL1A | P56279 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
TCL1A | P56279 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
TCL1A | P56279 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
TCL1A | P56279 | WDR47 | Homo sapiens | O94967 | 25416956 | |
|
Intra
|
TCL1A | P56279 | WDR47 | Homo sapiens | O94967 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 33961781 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 31515488 | |
|
Intra
|
TCL1A | P56279 | CALCOCO2 | Homo sapiens | Q13137 | 16189514 | |
|
Intra
|
TCL1A | P56279 | PRTFDC1 | Homo sapiens | Q9NRG1 | 25416956 | |
|
Intra
|
TCL1A | P56279 | PRTFDC1 | Homo sapiens | Q9NRG1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | PRTFDC1 | Homo sapiens | Q9NRG1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | PRTFDC1 | Homo sapiens | Q9NRG1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NIF3L1 | Homo sapiens | Q9GZT8 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NIF3L1 | Homo sapiens | Q9GZT8 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NIF3L1 | Homo sapiens | Q9GZT8 | 32296183 | |
|
Intra
|
TCL1A | P56279 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
TCL1A | P56279 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
TCL1A | P56279 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
TCL1A | P56279 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
TCL1A | P56279 | CEP55 | Homo sapiens | Q53EZ4 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CEP55 | Homo sapiens | Q53EZ4 | 27107012 | |
|
Intra
|
TCL1A | P56279 | CEP55 | Homo sapiens | Q53EZ4 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CEP55 | Homo sapiens | Q53EZ4 | 27107012 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 31515488 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 25416956 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 25416956 | |
|
Intra
|
TCL1A | P56279 | FLACC1 | Homo sapiens | Q96Q35 | 25416956 | |
|
Intra
|
TCL1A | P56279 | FLACC1 | Homo sapiens | Q96Q35 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CARD9 | Homo sapiens | Q9H257 | 25416956 | |
|
Intra
|
TCL1A | P56279 | CARD9 | Homo sapiens | Q9H257 | 25416956 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 33961781 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | DNMT3A | Homo sapiens | Q9Y6K1 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRMT61A | Homo sapiens | Q96FX7 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRMT61A | Homo sapiens | Q96FX7 | 32296183 | |
|
Intra
|
TCL1A | P56279 | TRMT61A | Homo sapiens | Q96FX7 | 32296183 |
Recombinant TCL1A Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P74530 | TCL1A Protein, Human (His) | P56279 (A2-D114) | ≥ 85%, as determined by reducing SDS-PAGE. |
TCL1A Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P81959 | T Cell Leukemia/Lymphoma Protein 1A Antibody (YA1704) | WB, IHC-P, ICC/IF, FC | Human |
| HY-P85928 | T Cell Leukemia/Lymphoma Protein 1A Antibody (YA5620) | IHC-P, WB, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Precursor T-Cell Acute Lymphoblastic Leukemia |
|
|
| Leukemia |
|
|
| Prolymphocytic Leukemia |
|
|
| Lymphoma |
|
|
| T-Cell Prolymphocytic Leukemia |
|
|
| Peripheral T-Cell Lymphoma |
|
|
| Lymphoma Aids Related |
|
|
| Burkitt Lymphoma |
|
|
| Seminoma |
|
|
| Ataxia-Telangiectasia |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| B-Cell Lymphoma |
|
|
| Bn2 Diffuse Large B-Cell Lymphoma |
|
|
| Lymphoproliferative Syndrome |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Richter'S Syndrome |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Follicular Lymphoma |
|
|
| Mantle Cell Lymphoma |
|
|
| Myeloma, Multiple |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | TCL1A | MGD | MGI:1097166 |
| Rattus norvegicus | TCL1A | RGD | RGD:1594686 |
| Bos taurus | TCL1A | VGNC | VGNC:99734 |
| Others | TCL1A | NCBI |