POLDIP3 - DNA polymerase delta interacting protein 3 Gene

Also Known as SKAR; PDIP3; PDIP46

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84271

About POLDIP3

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,583,721-42,614,883 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 49.2), bone marrow (RPKM 26.9) and 25 other tissues.

Summary

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

POLDIP3 Products (4)

mRNA Protein Name
NM_001278657.2 NP_001265586.1 polymerase delta-interacting protein 3 isoform 3
NM_001363052.2 NP_001349981.1 polymerase delta-interacting protein 3 isoform 4
NM_032311.5 NP_115687.2 polymerase delta-interacting protein 3 isoform 1
NM_178136.3 NP_835237.1 polymerase delta-interacting protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
18423201 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
18423201 GOA
Biological Process GO Annotation Evidence Références Source
involved in poly(A)+ mRNA export from nucleus IDA
IDA: Inferred from direct assay
22928037 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
18423201 GOA
Cellular Component GO Annotation Evidence Références Source
located in nuclear speck IDA
IDA: Inferred from direct assay
18423201 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLDIP3 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (284 - 344)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

polymerase delta-interacting protein 3

  • 46 kDa DNA polymerase delta interaction protein

POLDIP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
POLDIP3 Q9BY77 NCBP1 Homo sapiens Q09161
Anti Bait CoIP
18423201
Intra
POLDIP3 Q9BY77 UBR1 Homo sapiens Q8IWV7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Methylmalonic Aciduria, Cblb Type

  • Methylmalonic Aciduria Cblb Type

  • Methylmalonic Acidemia Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

  • Methylmalonic Acidemia, Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

  • Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

  • Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

  • Methylmalonic Aciduria Type Cblb

  • MMAB

  • Methylmalonic Aciduria Type B

  • Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

  • Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

  • Aciduria, Methylmalonic, Cblb Type

  • Methylmalonic Acidemia

  • Methylmalonic Aciduria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10824 POLDIP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POLDIP3 MGD MGI:1921076
Canis familiaris POLDIP3 VGNC VGNC:44778
Rattus norvegicus POLDIP3 RGD RGD:1311073
Macaca mulatta POLDIP3 VGNC VGNC:97119
Bos taurus POLDIP3 VGNC VGNC:33117
Felis catus POLDIP3 VGNC VGNC:64284
Others POLDIP3 NCBI