CD164 - CD164 molecule Gene

Also Known as DFNA66; MGC-24; MUC-24; MGC-24v; endolyn

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8763

About CD164

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,366,514-109,382,467 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 246.6), fat (RPKM 191.2) and 25 other tissues.

Summary

This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C Chemokine Receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood Cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]

CD164 Products (6)

mRNA Protein Name
NM_001142401.3 NP_001135873.1 sialomucin core protein 24 isoform 2 precursor
NM_001142402.3 NP_001135874.1 sialomucin core protein 24 isoform 3 precursor
NM_001142403.3 NP_001135875.1 sialomucin core protein 24 isoform 4 precursor
NM_001142404.3 NP_001135876.1 sialomucin core protein 24 isoform 5 precursor
NM_001346500.2 NP_001333429.1 sialomucin core protein 24 isoform 6
NM_006016.6 NP_006007.2 sialomucin core protein 24 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
17077324 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
10491205 GOA
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
10491205 GOA
Cellular Component GO Annotation Evidence Références Source
located in endosome IDA
IDA: Inferred from direct assay
11027692 GOA
located in lysosome IDA
IDA: Inferred from direct assay
11027692 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10491205 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD164 Protein Structure

MGC-24

MGC-24: Multi-glycosylated core protein 24 (MGC-24), sialomucin (5 - 189)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

sialomucin core protein 24

  • CD164 antigen, sialomucin

CD164 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CD164 Q04900 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
CD164 Q04900 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
CD164 Q04900 CXCR4 Homo sapiens P61073
Anti Bait CoIP
24094005
Intra
CD164 Q04900 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
CD164 Q04900 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
CD164 Q04900 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD164 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75617 CD164 Protein, Human (HEK293, His) Q04900-1 (D24-D162) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 66

  • DFNA66

  • Autosomal Dominant Nonsyndromic Deafness 66

  • Autosomal Dominant Deafness 66

  • Deafness, Autosomal Dominant, 66
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

  • Autosomal Dominant Isolated Neurosensory Deafness Type Dfna

  • Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna

  • Autosomal Dominant Isolated Sensorineural Deafness Type Dfna

  • Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna

  • Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna

  • Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna

  • Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Lymphocytic Choriomeningitis

  • Lcm

  • Lymphocytic Meningitis

  • Lymphocytic Choriomeningitis Virus Encephalomyelitis

  • Lymphocytic Meningoencephalitis

  • Non-Arthropod Borne Lymphocytic Choriomeningitis

  • Lcm - [Lymphocytic Choriomeningitis]

  • Benign Lymphocytic Meningitis

  • Meningitis Due To Lymphocytic Choriomeningitis Virus
Sensorineural Hearing Loss

  • Sensory Hearing Loss

  • Sensorineural Deafness

  • Sensorineural Hearing Loss Disorder

  • Hearing Loss, Sensorineural

  • Central Hearing Loss

  • High Frequency Deafness

  • High Frequency Hearing Loss

  • High-Frequency Hearing Loss

  • Perceptive Deafness

  • Perceptive Hearing Loss

  • Perceptive Hearing Loss Or Deafness

  • Hearing Loss Sensorineural

  • Deafness Sensorineural

  • Hearing Loss High-Frequency

  • Hearing Loss, Central

  • Hearing Loss, High-Frequency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02194 CD164 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02195 CD164L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17603 Cd164 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24063 Cd164 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD164 VGNC VGNC:70753
Felis catus CD164 VGNC VGNC:102397
Rattus norvegicus CD164 RGD RGD:70942
Mus musculus CD164 MGD MGI:1859568
Bos taurus CD164 VGNC VGNC:27004
Canis familiaris CD164 VGNC VGNC:38932
Others CD164 NCBI