SNAP23 - synaptosome associated protein 23 Gene

Also Known as SNAP-23; SNAP23A; SNAP23B; HsT17016

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8773

About SNAP23

Cytogenetic location: 15q15.1-q15.2 Genomic coordinates (GRCh38): 15:42,491,129-42,533,058 (from NCBI)

This gene has 23 transcripts (splice variants), 228 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 25.6), appendix (RPKM 23.5) and 25 other tissues.

Summary

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in Other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

SNAP23 Products (2)

mRNA Protein Name
NM_003825.4 NP_003816.2 synaptosomal-associated protein 23 isoform SNAP23A
NM_130798.3 NP_570710.1 synaptosomal-associated protein 23 isoform SNAP23B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12773094 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
16677249 GOA
Biological Process GO Annotation Evidence Références Source
involved in histamine secretion by mast cell IMP
IMP: Inferred from mutant phenotype
18253931 GOA
Cellular Component GO Annotation Evidence Références Source
part of SNARE complex IDA
IDA: Inferred from direct assay
18253931 GOA
located in adherens junction IDA
IDA: Inferred from direct assay
25468996 GOA
located in azurophil granule IDA
IDA: Inferred from direct assay
18588921 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18457912 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
26733245 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18253931 GOA
located in specific granule IDA
IDA: Inferred from direct assay
18588921 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNAP23 Protein Structure

SNAP-25

SNAP-25: SNAP-25 family (86 - 147)

SNARE

SNARE: SNARE domain (151 - 208)

  • 0
  • 100
  • 200
  • 211 a.a.
Protein Preferred Names Protein Names

synaptosomal-associated protein 23

  • synaptosomal-associated protein, 23kD

SNAP23 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SNAP23 O00161 NAPB Homo sapiens Q9H115
Y2H Prey Pooling
25416956
Intra
SNAP23 O00161 NAPB Homo sapiens Q9H115
Y2H Array
25416956
Intra
SNAP23 O00161 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra
SNAP23 O00161 STX11 Homo sapiens O75558
Y2H
21900206
Intra
SNAP23 O00161 STX11 Homo sapiens O75558
Validated Y2H
32296183
Intra
SNAP23 O00161 SCGN Homo sapiens O76038
Y2H Pooling
16189514
Intra
SNAP23 O00161 NAPA Homo sapiens P54920
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

SNAP23 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82682 SNAP23 Antibody (YA2427) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Tetanus

  • Lockjaw

  • Clostridial Tetanus

  • Infection Due To Clostridium Tetani

  • Lock-Jaw
Chief Cell Adenoma

  • Chief Cell Adenoma Of Parathyroid Gland
Hemophagocytic Lymphohistiocytosis, Familial, 4

  • Familial Hemophagocytic Lymphohistiocytosis 4

  • FHL4

  • Hplh4

  • Hlh4

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Foodborne Botulism

  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome

  • Cednik Syndrome

  • CEDNIK

  • Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome

  • Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro

  • Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome

  • Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome

  • Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma

  • Neurocutaneous Syndromes
Familial Hemophagocytic Lymphohistiocytosis 5

  • Fhl5

  • Hlh5

  • Hplh5

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 5
Lesion Of Sciatic Nerve

  • Nerve Lesion Sciatic

  • Sciatic Neuropathy
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13473 SNAP23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SNAP23 VGNC VGNC:65515
Rattus norvegicus SNAP23 RGD RGD:620221
Macaca mulatta SNAP23 VGNC VGNC:77662
Mus musculus SNAP23 MGD MGI:109356
Canis familiaris SNAP23 VGNC VGNC:46587
Bos taurus SNAP23 VGNC VGNC:35050
Others SNAP23 NCBI