PHLDB2 - pleckstrin homology like domain family B member 2 Gene

Also Known as LL5b; LL5beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90102

About PHLDB2

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:111,732,496-111,976,517 (from NCBI)

This gene has 18 transcripts (splice variants), 319 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 18.1), kidney (RPKM 15.7) and 24 other tissues.

Summary

Enables Cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of Cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cell leading edge; and intermediate filament Cytoskeleton. Colocalizes with focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

PHLDB2 Products (4)

mRNA	Protein	Name
NM_001134437.2	NP_001127909.1	pleckstrin homology-like domain family B member 2 isoform b
NM_001134438.2	NP_001127910.1	pleckstrin homology-like domain family B member 2 isoform a
NM_001134439.2	NP_001127911.1	pleckstrin homology-like domain family B member 2 isoform a
NM_145753.2	NP_665696.1	pleckstrin homology-like domain family B member 2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20236936	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in negative regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in negative regulation of wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	24859005	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IGI IGI: Inferred from genetic interaction	23940118	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	23940118	GOA
involved in regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23940118	GOA
involved in regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	23940118	GOA
involved in regulation of microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	23940118	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in basal cortex	IDA IDA: Inferred from direct assay	23940118	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	24120883	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	24859005	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	24859005	GOA
located in podosome	IDA IDA: Inferred from direct assay	23525008	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHLDB2 Protein Structure

PH

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1253 a.a.

Protein Preferred Names	Protein Names
pleckstrin homology-like domain family B member 2	LL5 beta

PHLDB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PHLDB2	Q86SQ0	FLNA	Homo sapiens	P21333	Anti Tag CoIP	20236936

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS10446	PHLDB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHLDB2	VGNC	VGNC:49874
Bos taurus	PHLDB2	VGNC	VGNC:32838
Rattus norvegicus	PHLDB2	RGD	RGD:1591402
Mus musculus	PHLDB2	MGD	MGI:2444981
Macaca mulatta	PHLDB2	VGNC	VGNC:75883
Others	PHLDB2	NCBI