2. Gene
  3. PHLDB2 - pleckstrin homology like domain family B member 2 Gene

PHLDB2 - pleckstrin homology like domain family B member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LL5b; LL5beta

Gene ID: 90102 | Gene type: protein coding

About PHLDB2

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:111,732,496-111,976,517 (from NCBI)

This gene has 18 transcripts (splice variants), 319 orthologues and 7 paralogues. Ubiquitous expression in placenta (RPKM 18.1), kidney (RPKM 15.7) and 24 other tissues.

Summary

Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of Cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cell leading edge; and intermediate filament Cytoskeleton. Colocalizes with focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

PHLDB2 Products(4)

mRNA Protein Name
NM_001134437.2 NP_001127909.1 pleckstrin homology-like domain family B member 2 isoform b
NM_001134438.2 NP_001127910.1 pleckstrin homology-like domain family B member 2 isoform a
NM_001134439.2 NP_001127911.1 pleckstrin homology-like domain family B member 2 isoform a
NM_145753.2 NP_665696.1 pleckstrin homology-like domain family B member 2 isoform c

PHLDB2 Protein Structure

PH

PH: PH domain (1146 - 1241)

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  • 1253 a.a.
Protein Preferred Names Protein Names

pleckstrin homology-like domain family B member 2

LL5 beta

Related Diseases

Diseases Alias
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10446 PHLDB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PHLDB2 VGNC VGNC:49874
Bos taurus PHLDB2 VGNC VGNC:32838
Rattus norvegicus PHLDB2 RGD RGD:1591402
Mus musculus PHLDB2 MGD MGI:2444981
Macaca mulatta PHLDB2 VGNC VGNC:75883