TCEAL1 - transcription elongation factor A like 1 Gene

Also Known as p21; SIIR; WEX9; pp21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9338

About TCEAL1

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,628,716-103,630,953 (from NCBI)

This gene has 4 transcripts (splice variants), 82 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 48.1), endometrium (RPKM 41.3) and 24 other tissues.

Summary

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with Other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

TCEAL1 Products (3)

mRNA Protein Name
NM_001006639.2 NP_001006640.1 transcription elongation factor A protein-like 1
NM_001006640.2 NP_001006641.1 transcription elongation factor A protein-like 1
NM_004780.3 NP_004771.2 transcription elongation factor A protein-like 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
7971997 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCEAL1 Protein Structure

BEX

BEX: Brain expressed X-linked like family (1 - 158)

  • 0
  • 100
  • 159 a.a.
Protein Preferred Names Protein Names

transcription elongation factor A protein-like 1

  • TCEA-like protein 1

TCEAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TCEAL1 Q15170 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra
TCEAL1 Q15170 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amelogenesis Imperfecta, Hypomaturation Type, Iia3

  • Amelogenesis Imperfecta Hypomaturation Type 2a3

  • AI2A3

  • Amelogenesis Imperfecta Hypomaturation Type Iia3

  • Amelogenesis Imperfecta, Type Iia3

  • Amelogenesis Imperfecta Type Iia3

  • Amelogenesis Imperfecta, Hypomaturation Type, 2a3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14294 TCEAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TCEAL1 VGNC VGNC:66017
Canis familiaris TCEAL1 VGNC VGNC:49659
Bos taurus TCEAL1 VGNC VGNC:49978
Macaca mulatta TCEAL1 VGNC VGNC:78282
Mus musculus TCEAL1 MGD MGI:2385317
Rattus norvegicus TCEAL1 RGD RGD:1549724
Others TCEAL1 NCBI