HBV-IN-22
HBV-IN-22 (Compound LC5f) is an inhibitor of HBV DNA replication with IC50 values of 0.71 μM and 0.84 μM against wild-type and agent resistant HBV strains, respectively.
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- CAS No.: 2338573-94-5
- Formule: C26H29N3O2S2
- Masse moléculaire:479.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
IC50: 0.71 µM (wild-type HBV DNA replication), 0.84 µM (drug resistant HBV DNA replication)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | CC50 |
>10 μM
Compound: LC5f
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Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay
Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay
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[PMID: 35123297] |
| HepG2 2.2.15 | CC50 |
15.79 μM
Compound: 5f
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Cytotoxicity against human HepG2.2.15 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 31091479] |
| HepG2 2.2.15 | IC50 |
0.83 μM
Compound: LC5f
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Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication
Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication
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[PMID: 35123297] |
Chemical Information
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CAS No. 2338573-94-5
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Masse moléculaire 479.66
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Formule C26H29N3O2S2
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SMILES
CCN(CCOC1=CC=C2N=C(N(C(C2=C1)=O)CC3=CC=CS3)SCC4=CC=CC=C4)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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PCNA Immunodetection Proliferation Assay
PCNA immunodetection measures proliferative activity by detecting proliferating cell nuclear antigen, a nuclear protein associated with DNA polymerase δ function and DNA replication. The assay readout is the proportion of PCNA-positive nuclei among total counted cells, but PCNA labeling is not identical to BrdU labeling because PCNA can mark late G1/early S-associated replication competence and may persist beyond active DNA synthesis depending on fixation and extraction conditions.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HBV-IN-22 Related Classifications
HY-146394 Related Classifications
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