IHVR-17028
Based on 1 Customer Validation
IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.61%
- CAS No.: 1428247-78-2
- Formule: C23H44N2O5
- Masse moléculaire:428.61
-
Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
500 μM
Compound: 24
|
Cytotoxicity against human Huh7.5 cells by MTT assay
Cytotoxicity against human Huh7.5 cells by MTT assay
|
[PMID: 23453839] |
| Huh-7 | CC50 |
500 μM
Compound: 3
|
Cytotoxicity against human Huh7.5 cells by MTT assay
Cytotoxicity against human Huh7.5 cells by MTT assay
|
[PMID: 23747225] |
| Huh-7 | EC50 |
0.2 μM
Compound: 3
|
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis
|
[PMID: 23747225] |
| Huh-7 | EC50 |
0.2 μM
Compound: 24
|
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells
Antiviral activity against Tacaribe virus infected in human Huh7.5 cells
|
[PMID: 23453839] |
In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC50 values of all >500 μM in?MDBK, Huh7.5 or BHK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection[1]
-
Dosage:50 mg/kg
-
Administration:Treatment 1 day prior to virus challenging
-
Result:Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.
-
Animal Model:C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV[1]
-
Dosage:25 mg/kg
-
Administration:Twice daily at 12 h interval; starting 4 h post infection for 10 days
-
Result:Inhibited EBOV infection in mice.
Chemical Information
-
CAS No. 1428247-78-2
-
Appearance Oil
-
Masse moléculaire 428.61
-
Formule C23H44N2O5
-
Color Colorless to light yellow
-
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
-
Fiche technique (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IHVR-17028 Related Classifications
HY-139663 Related Classifications
Powered by Bioz