Jun9-72-2
Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC50 value of 0.67 μM. Jun9-72-2 has antiviral activity.
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- CAS No.: 2657659-42-0
- Formule: C20H21NO
- Masse moléculaire:291.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
23.69 μM
Compound: Jun9-72-2
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Cytotoxicity against African green monkey Vero E6 cells incubated for 48 hrs by neutral red uptake assay
Cytotoxicity against African green monkey Vero E6 cells incubated for 48 hrs by neutral red uptake assay
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[PMID: 38065031] |
Chemical Information
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CAS No. 2657659-42-0
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Masse moléculaire 291.39
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Formule C20H21NO
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SMILES
OC(C=C1)=CC=C1CN(C)[C@@H](C2=CC=CC3=C2C=CC=C3)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Jun9-72-2 Related Classifications
HY-158751 Related Classifications
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