KRO-105714
KRO-105714 is the antagonist for sphingosine phosphocholine receptor (SPC Receptor) and sphingosine-1-phosphate receptor 1 (S1P1 Receptor) (IC50=79.2 nM). KRO-105714 inhibits SPC-induced proliferation of NIH3T3 (IC50=5.6 nM), inhibits SPC-induced cell migration (IC50=0.59 μM) and tube formation in HUVECs. KRO-105714 inhibits SPC-induced generation of IL-4 and IL-5, exhibits anti-inflammtory efficacy in mouse atopic dermatitis models.
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- CAS No.: 1137536-21-0
- Formule: C26H30N4O3S
- Masse moléculaire:478.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 1137536-21-0
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Masse moléculaire 478.61
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Formule C26H30N4O3S
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SMILES
O=C(C1=C(NC(C(C)(C)C)=O)N=C(N2CCN(CC2)C3=C(OC)C=CC=C3)S1)C4=CC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRO-105714 Related Classifications
HY-169864 Related Classifications
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