LSD1-IN-49
LSD1-IN-49 is a Lysine-specific demethylase 1 (LSD1/KDM1A) inhibitor with a human IC50 of 29 nM. LSD1-IN-49 irreversibly inhibits LSD1 enzyme activity by forming an adduct with the flavin adenine dinucleotide (FAD) cofactor of LSD1. LSD1-IN-49 can be used as a lead compound for the development of LSD1-targeted PET imaging agents for the brain.
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- CAS No.: 1422533-70-7
- Formule: C26H26N2O
- Masse moléculaire:382.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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LSD1 29 nM (IC50) |
LSD1-IN-49 (compound (±)1) (15 min) potently inhibits human recombinant LSD1/CoREST enzyme with an IC50 of 29 nM[1].
LSD1-IN-49 (1 μM; 1 h) has an MDR1 efflux ratio of 0.8 when tested in human MDR1-expressing LLC-PK1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1422533-70-7
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Masse moléculaire 382.50
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Formule C26H26N2O
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SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC(C=C3)=CC=C3[C@H](C4)[C@@H]4NCC5CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-49 Related Classifications
HY-186116 Related Classifications
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