MLKL ligand-2
MLKL ligand-2 is a mixed lineage kinase domain-like pseudokinase (MLKL) PROTAC ligand with a KD of 9.408 μM. MLKL ligand-2 forms hydrogen bond networks and hydrophobic interactions with specific MLKL residues, and stabilizes MLKL in hepatic cells. MLKL ligand-2 can be used to synthesize PROTAC MLKL Degrader-3 (HY-182343).
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- Formule: C30H30F4N8O3S
- Masse moléculaire:658.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
MLKL ligand-2 (Compound 5) (1.563-5.000 μM) binds to purified MLKL protein with a KD of 9.408 μM[1].
MLKL ligand-2 (25 μM; 4 h) stabilizes MLKL protein in Hepa1−6 cells, confirming cellular target engagement[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hepa1−6 cells
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Concentration:25 μM
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Incubation Time:4 h
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Result:Stabilized MLKL protein.
Chemical Information
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Masse moléculaire 658.67
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Formule C30H30F4N8O3S
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SMILES
NC1=C(C2=C(C=N1)C3=CN(N=C3)C4CCNCC4)C(C5=CC(OC(C6=CC=C(C=C6)F)C)=C(C=C5F)NS(=O)(C(F)F)=O)=NN2C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLKL ligand-2 Related Classifications
HY-182344 Related Classifications
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