mPEG-PCL
mPEG-PCL is an amphiphilic biodegradable block copolymer composed of hydrophilic methoxy poly (ethylene glycol) (mPEG) and hydrophobic poly (ε-caprolactone) (PCL). mPEG-PCL possesses excellent biocompatibility and can form delivery carriers such as micelles and nanoparticles. Through its amphiphilic block structure, mPEG-PCL forms nanocarriers and encapsulates hydrophobic molecules, thereby enhancing the loading capacity of hydrophobic molecules, reducing burst release, and achieving sustained release. mPEG-PCL can be used in research on nanodelivery, tissue engineering, and ocular delivery systems related to age-related macular degeneration (AMD).
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- Masse moléculaire:2000-5000 (Approximately)
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Blank mPEG-PCL micelles (0.001-20 μM; 24-48 h) exhibit excellent cytocompatibility when applied to ARPE-19 human retinal pigment epithelial cells, with cell viability higher than 88% at 24 h and higher than 95% at 48 h across all tested concentrations[1].
mPEG-PCL (120°C) is a mPEG-PCL diblock copolymer prepared using mPEG as a macroinitiator via ring-opening polymerization of ε-caprolactone at 120°C with stannous octoate or other metal-based catalysts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ARPE-19 human retinal pigment epithelial cells
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Concentration:0.001, 0.01, 0.1, 1, 10, 20 μM
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Incubation Time:24 h, 48 h
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Result:Maintained >88% cell viability across all tested concentrations at 24 h.
Maintained >95% cell viability across all tested concentrations at 48 h.
Reached the highest cell viability of 99.25% at selected low concentrations at 24 h.
Showed no significant cytotoxicity in ARPE-19 cells.
Chemical Information
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Masse moléculaire 2000-5000 (Approximately)
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SMILES
[mPEG-PCL]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
mPEG-PCL Related Classifications
HY-W888515 Related Classifications
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