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Cat. No.: HY-106111

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Nafagrel

Name: Nafagrel
Brand: MedChemExpress
SKU: HY-106111
Availability: PreOrder

(Synonyms: DP-1904 free acid)

Nafagrel (DP-1904 free acid) is a Thromboxane A₂ synthase inhibitor. Nafagrel inhibits the production of Thromboxane A₂ and increases the production of Prostaglandin I₂ (HY-A0126A). Nafagrel prevents thrombotic material accumulation in acute arterial thrombosis models. Nafagrel can be used in research on peripheral vascular disease, restenosis after PTCA, and lupus nephritis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 97901-21-8
Formule: C₁₅H₁₆N₂O₂
Masse moléculaire:256.31

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nafagrel Chemical Structure

CAS No.: 97901-21-8

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Prostaglandin Receptor :

In Vitro

Lipid Inflammatory MediatorsLocal Vascular RegulationOthers

Lipid Inflammatory Mediators

Local Vascular Regulation

DP-1904 (0.1 μM-1 mM; 2 h) completely suppresses TXB₂ production and dramatically increases 6-keto-PGF_1α production from human umbilical vein EC and platelets stimulated by HA-IgG in a coculture system, acting as a TXA₂ synthetase inhibitor^[3].

Others

Nafagrel inhibits thromboxane synthase as an imidazole derivative^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[3]

Cell Line:

Human umbilical vein endothelial cells and human platelets
Concentration:

10^-3, 10^-4, 10^-5, 10^-6, 10^-7 M
Incubation Time:

2 h
Result:

Suppressed TXB2 production at 10^-3 to 10^-6 M to levels similar to controls.
Increased 6-keto-PGF1α production at 10^-4 to 10^-7 M.
Decreased the TXB2/6-keto-PGF1α ratio at all concentrations.

In Vivo

Local Vascular Regulation

Nafagrel inhibits the accumulation of thrombotic material in a rat model of acute arterial thrombosis, whereas ASA is ineffective^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 97901-21-8
Masse moléculaire 256.31
Formule C₁₅H₁₆N₂O₂
SMILES

O=C(O)C1=CC=C2C(=C1)CCC(C2)CN3C=NC=C3
Synonyms

DP-1904 free acid
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Geiger J, et al. Inhibitors of platelet signal transduction as anti-aggregatory drugs. Expert opinion on investigational drugs. 2001 May;10(5):865-90. [Content Brief]

[2]. Herrman J P R, et al. Pharmacological approaches to the prevention of restenosis following angioplasty: the search for the Holy Grail?(Part I)[J]. Drugs, 1993, 46(1): 18-52.

[3]. Kaneko N, et al. Production of thromboxane A2 and prostaglandin i2 affected by interaction of heat aggregated IgG, endothelial cells, and platelets in lupus nephritis. The Journal of rheumatology. 2002 Oct;29(10):2106-13.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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