NCX-278
NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM Ki for hCA II, 410 nM Ki for hCA I, 181 nM Ki for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC50 of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma.
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- CAS No.: 1202697-61-7
- Formule: C14H21N3O9S3
- Masse moléculaire:471.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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hCA II 13 nM (Ki) |
hCA I 410 nM (Ki) |
NCX-278 potently inhibits recombinant human hCA II with a Ki of 13 nM, and shows 13.9-fold selectivity for hCA II over hCA IV, while inhibiting hCA I with a Ki of 410 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax |
|---|---|---|---|
| Rat[1] | 55 mM | o.a. | 120 min |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand white rabbits[1]
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Dosage:55 mM
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Administration:o.a.; single dose
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Result:Reduced intraocular pressure to a maximal effect of -3.7 mmHg.
Reached peak effect at 120 minutes post-dosing.
Returned to basal intraocular pressure levels at 360 minutes post-dosing.
Chemical Information
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CAS No. 1202697-61-7
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Masse moléculaire 471.53
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Formule C14H21N3O9S3
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SMILES
O=C(OCCCO[N+]([O-])=O)N([C@@H]1C2=C(S(=O)([C@H](C1)C)=O)SC(S(N)(=O)=O)=C2)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NCX-278 Related Classifications
HY-182426 Related Classifications
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