NIOCH 14
NIOCH 14 is a antiviral agent and a pro-agent. NIOCH 14 has antiviral activity against orthopoxviruses. NIOCH 14 can significantly lower proportions of infected mice, and virus production levels in the lungs. NIOCH 14 can be used for researching anti-smallpox. NIOCH 14 shows anti-orthopoxvirus activity.
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- CAS No.: 1268015-38-8
- Formule: C19H17F3N2O4
- Masse moléculaire:394.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Orthopoxviruses[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
1193.4 μM
Compound: NIOCH-14
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Cytotoxicity against African green monkey Vero cells measured after 4 days by colorimetric assay
Cytotoxicity against African green monkey Vero cells measured after 4 days by colorimetric assay
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[PMID: 36414175] |
| Vero | EC50 |
0.011 μg/mL
Compound: 58; NIOCH-14
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Antiviral activity against ectromelia virus K-1 infected in Vero cells measured after 4 days by colorimetric assay
Antiviral activity against ectromelia virus K-1 infected in Vero cells measured after 4 days by colorimetric assay
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[PMID: 36961984] |
| Vero | EC50 |
0.013 μg/mL
Compound: 58; NIOCH-14
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Antiviral activity against Monkeypox virus V79-1-005 infected in Vero cells measured after 4 days by colorimetric assay
Antiviral activity against Monkeypox virus V79-1-005 infected in Vero cells measured after 4 days by colorimetric assay
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[PMID: 36961984] |
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1268015-38-8
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Masse moléculaire 394.34
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Formule C19H17F3N2O4
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SMILES
O=C(C1C2C=CC(C3CC23)C1C(NNC(C4=CC=C(C(F)(F)F)C=C4)=O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sokolova AS, et al. (+)-Camphor and (-)-borneol derivatives as potential anti-orthopoxvirus agents. Arch Pharm (Weinheim). 2021;354(6):e2100038. [Content Brief]
[2]. Mazurkov OY, et al. New effective chemically synthesized anti-smallpox compound NIOCH-14. J Gen Virol. 2016;97(5):1229-1239. [Content Brief]
[3]. Anastasiya S Sokolova, et al. (+)-Camphor and (-)-borneol derivatives as potential anti-orthopoxvirus agents. Arch Pharm (Weinheim). 2021 Jun;354(6):e2100038. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NIOCH 14 Related Classifications
HY-147016 Related Classifications
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