P-CAB agent 1
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs).
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- CAS No.: 2374139-68-9
- Formule: C26H23FN4O
- Masse moléculaire:426.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 60.50 nM (H+/K+-ATPase)[1]
Pharmacokinetic Parameters of P-CAB agent 1 in female Sprague-Dawley rats[1].
| IV (2 mg/kg) | PO (8 mg/kg) | |
| AUC0-∞ (ug/L*hr) | 519.57 | 341.49 |
| t1/2 (ng/mL) | 0.49 | 0.8 |
| Cmax (ug/L) | 149.93 | 17 |
| F (%) | 16.43 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2374139-68-9
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Masse moléculaire 426.49
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Formule C26H23FN4O
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SMILES
O=C(N)C1=CC(C2=CC=CC(CN3N=C4CN(CC4=C3C5=CC=CC=C5F)C)=C2)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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