PC DBCO-PEG4-NHS ester
Based on 1 Customer Validation
PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- Pureté: 96.85%
- CAS No.: 2055025-02-8
- Formule: C47H55N5O16
- Masse moléculaire:945.96
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform PROTAC Linkers
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Activité biologique
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2055025-02-8
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Appearance Solid
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Masse moléculaire 945.96
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Formule C47H55N5O16
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Color White to light yellow
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SMILES
[O-][N+](C(C(C(OC(ON1C(CCC1=O)=O)=O)C)=C2)=CC(OCCCC(NCCOCCOCCOCCOCCC(NCCC(N3CC4=C(C=CC=C4)C#CC5=C3C=CC=C5)=O)=O)=O)=C2OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 250 mg/mL (264.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0571 mL | 5.2856 mL | 10.5713 mL | 26.4282 mL |
| 5 mM | 0.2114 mL | 1.0571 mL | 2.1143 mL | 5.2856 mL | |
| 10 mM | 0.1057 mL | 0.5286 mL | 1.0571 mL | 2.6428 mL | |
| 15 mM | 0.0705 mL | 0.3524 mL | 0.7048 mL | 1.7619 mL | |
| 20 mM | 0.0529 mL | 0.2643 mL | 0.5286 mL | 1.3214 mL | |
| 25 mM | 0.0423 mL | 0.2114 mL | 0.4229 mL | 1.0571 mL | |
| 30 mM | 0.0352 mL | 0.1762 mL | 0.3524 mL | 0.8809 mL | |
| 40 mM | 0.0264 mL | 0.1321 mL | 0.2643 mL | 0.6607 mL | |
| 50 mM | 0.0211 mL | 0.1057 mL | 0.2114 mL | 0.5286 mL | |
| 60 mM | 0.0176 mL | 0.0881 mL | 0.1762 mL | 0.4405 mL | |
| 80 mM | 0.0132 mL | 0.0661 mL | 0.1321 mL | 0.3304 mL | |
| 100 mM | 0.0106 mL | 0.0529 mL | 0.1057 mL | 0.2643 mL |
PC DBCO-PEG4-NHS ester Related Classifications
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