PD 161374

PD 161374 is effective against all tested HIV-1, HIV-2 and SIV strains, with the EC₅₀ range being between 1.3 and 9.5 μM and it is also effective against AZT and protease inhibitor-resistant strains^[1].
PD 161374 (48 h) effectively inhibits the infection of HeLa Magi cells by HIV when added within 0-4 hours after infection, but added 6 hours after infection, it completely lost its protective effect^[1].
PD 161374 (4-24 h) significantly delayed and disrupted the normal progression and completion of the reverse transcription process in H9 cells infected with HIV-1 IIIB, resulting in the inability of viral DNA to successfully enter the nucleus and circularize^[1].
PD 161374 (20 μM, 48 h) only slightly inhibits (20-40%) the release of the virus on chronically infected H9/HIV-III^[1].
PD 161374 shows an EC₅₀ of 1.3 µM and no cytotoxicity up to 100 µM in T cell culture^[2].
PD 161374 delays the appearance of completed HIV-cDNA products including 2-LTR circles^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.