PE 22-28
Based on 1 Customer Validation
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.98%
- CAS No.: 1801959-12-5
- Formule: C35H55N11O9
- Masse moléculaire:773.88
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.12 nM (TREK-1)[1]
PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Naïve male C57Bl/6J mice[1]
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Dosage:3.0µg/kg
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Administration:Intraperitoneal
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Result:Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.
Chemical Information
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CAS No. 1801959-12-5
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Appearance Solid
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Masse moléculaire 773.88
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Formule C35H55N11O9
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Color White to off-white
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Sequence
Gly-Val-Ser-Trp-Gly-Leu-Arg
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Sequence Shortening
GVSWGLR
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 50 mg/mL (64.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 21.7 mg/mL (28.04 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.2922 mL | 6.4609 mL | 12.9219 mL | 32.3047 mL |
| 5 mM | 0.2584 mL | 1.2922 mL | 2.5844 mL | 6.4609 mL | |
| 10 mM | 0.1292 mL | 0.6461 mL | 1.2922 mL | 3.2305 mL | |
| 15 mM | 0.0861 mL | 0.4307 mL | 0.8615 mL | 2.1536 mL | |
| 20 mM | 0.0646 mL | 0.3230 mL | 0.6461 mL | 1.6152 mL | |
| 25 mM | 0.0517 mL | 0.2584 mL | 0.5169 mL | 1.2922 mL | |
| DMSO | 30 mM | 0.0431 mL | 0.2154 mL | 0.4307 mL | 1.0768 mL |
| 40 mM | 0.0323 mL | 0.1615 mL | 0.3230 mL | 0.8076 mL | |
| 50 mM | 0.0258 mL | 0.1292 mL | 0.2584 mL | 0.6461 mL | |
| 60 mM | 0.0215 mL | 0.1077 mL | 0.2154 mL | 0.5384 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PE 22-28 Related Classifications
HY-P3581 Related Classifications
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